Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease

AIMS: Cellular senescence plays a role in organismal ageing and has been linked to persistent DNA damage in age‐related diseases. Brain senescence has been described in astrocytes and microglia, but it is less well understood in neurones. Evidence suggests that neurones activate a senescence‐like me...

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Detalles Bibliográficos
Autores principales: Vazquez‐Villaseñor, I., Garwood, C. J., Heath, P. R., Simpson, J. E., Ince, P. G., Wharton, S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217199/
https://www.ncbi.nlm.nih.gov/pubmed/31077599
http://dx.doi.org/10.1111/nan.12559

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