Cargando…

Dupilumab: Clinical Efficacy of Blocking IL-4/IL-13 Signalling in Chronic Rhinosinusitis with Nasal Polyps

In September 2019, The Lancet published details of two large Phase III double-blind placebo-controlled studies (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52) confirming the clinical efficacy of the biologic dupilumab in simultaneously blocking both IL-4/IL-13 signalling in chronic rhinosinusitis with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kariyawasam, Harsha H, James, Louisa K, Gane, Simon B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217316/ https://www.ncbi.nlm.nih.gov/pubmed/32440101 http://dx.doi.org/10.2147/DDDT.S243053

Ejemplares similares

Chronic Rhinosinusitis with Nasal Polyps: Targeting IgE with Anti-IgE Omalizumab Therapy
por: Kariyawasam, Harsha H, et al.
Publicado: (2020)

The Effect of Dupilumab on Intractable Chronic Rhinosinusitis with Nasal Polyps in Japan
por: Fujieda, Shigeharu, et al.
Publicado: (2020)

Chronic rhinosinusitis with and without nasal polyps and asthma: Omalizumab improves residual anxiety but not depression
por: Vogt, Florian, et al.
Publicado: (2021)

Rapid and sustained effects of dupilumab in severe chronic rhinosinusitis with nasal polyps
por: Hellings, Peter W., et al.
Publicado: (2022)

Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp
por: Ryu, Gwanghui, et al.
Publicado: (2020)

Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps
por: Chen, Jiun-Bo, et al.
Publicado: (2017)

Efficacy of dupilumab in patients with a history of prior sinus surgery for chronic rhinosinusitis with nasal polyps
por: Hopkins, Claire, et al.
Publicado: (2021)

Efficacy of Dupilumab in Concomitant Atopic Dermatitis and Chronic Rhinosinusitis With Nasal Polyps: A Preliminary Study
por: Nettis, Eustachio, et al.
Publicado: (2020)

Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS‐52 is unaffected by eosinophilic status
por: Fujieda, Shigeharu, et al.
Publicado: (2021)

Real‐life observational cohort verifies high efficacy of dupilumab for chronic rhinosinusitis with nasal polyps
por: van der Lans, Rik Johannes Leonardus, et al.
Publicado: (2021)

Dupilumab efficacy and biomarkers in chronic rhinosinusitis with nasal polyps: Association between dupilumab treatment effect on nasal polyp score and biomarkers of type 2 inflammation in patients with chronic rhinosinusitis with nasal polyps in the phase 3 SINUS‐24 and SINUS‐52 trials
por: Bachert, Claus, et al.
Publicado: (2022)

Therapeutic Potential of Dupilumab in the Treatment of Chronic Rhinosinusitis with Nasal Polyps: Evidence to Date
por: Kim, Jean, et al.
Publicado: (2020)

AROMA: real-world global registry of dupilumab for chronic rhinosinusitis with nasal polyps
por: Siddiqui, Shahid, et al.
Publicado: (2022)

Increased IL-1α expression in chronic rhinosinusitis with nasal polyps
por: Cao, Yujie, et al.
Publicado: (2022)

Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review
por: Nitro, Letizia, et al.
Publicado: (2022)

Dupilumab provides early and durable improvement of symptoms in patients with chronic rhinosinusitis with nasal polyps
por: Gevaert, Philippe, et al.
Publicado: (2023)

Association of IL-1 gene polymorphisms with chronic rhinosinusitis with and without nasal polyp
por: Mohamad, Sakinah, et al.
Publicado: (2019)

WITHDRAWN: Dupilumab: A review of potential in the treatment of Chronic rhinosinusitis with nasal polyps (CRSwNP)
por: Sree Sudha, T.Y., et al.
Publicado: (2020)

COVID-19 in a patient with severe chronic rhinosinusitis with nasal polyps during therapy with dupilumab
por: Förster-Ruhrmann, Ulrike, et al.
Publicado: (2020)

Management of chronic rhinosinusitis with nasal polyps in Samter triad by low-dose ASA desensitization or dupilumab
por: Bertlich, Mattis, et al.
Publicado: (2021)

Cost–Utility Analysis of Dupilumab for the Treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in Italy
por: De Corso, Eugenio, et al.
Publicado: (2022)

Comorbid asthma in patients with chronic rhinosinusitis with nasal polyps: did dupilumab make a difference?
por: Al-Ahmad, Mona, et al.
Publicado: (2023)

IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic
por: Xuan, Lijia, et al.
Publicado: (2022)

Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
por: Kim, Dong-Kyu, et al.
Publicado: (2020)

Effectiveness and Safety Profile of Dupilumab in Chronic Rhinosinusitis with Nasal Polyps: Real-Life Data in Tertiary Care
por: Galletti, Cosimo, et al.
Publicado: (2023)

Effect of Dupilumab on Type 2 Biomarkers in Chronic Rhinosinusitis With Nasal Polyps: SINUS-52 Study Results
por: Bachert, Claus, et al.
Publicado: (2023)

Differential expression of miR-4492 and IL-10 is involved in chronic rhinosinusitis with nasal polyps
por: Li, Linge, et al.
Publicado: (2019)

Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction
por: Bequignon, Emilie, et al.
Publicado: (2020)

Chronic rhinosinusitis with nasal polyps in the elderly
por: Cornet, Marjolein, et al.
Publicado: (2013)

Proposal for a Structured Outpatient Clinic for Dupilumab Treatment in Chronic Rhinosinusitis with Nasal Polyps in the First Year of Treatment
por: Torretta, Sara, et al.
Publicado: (2022)

Dupilumab Improves Outcomes in Patients with Chronic Rhinosinusitis with Nasal Polyps and Coexisting Asthma Irrespective of Baseline Asthma Characteristics
por: Busse, William Walter, et al.
Publicado: (2023)

Clinical outcomes of dupilumab therapy in chronic rhinosinusitis with nasal polyps in a Canadian tertiary care rhinology practice
por: Grose, Elysia, et al.
Publicado: (2023)

The argument against the use of dupilumab in patients with limited polyp burden in chronic rhinosinusitis with nasal polyposis (CRSwNP)
por: Hardison, Scott A., et al.
Publicado: (2023)

Impact of Chronic Rhinosinusitis with Nasal Polyposis on IL-12 and IL-8
por: do Amaral, Janatas Bussador, et al.
Publicado: (2023)

IL-5, IL-8 and tgf-beta expressions in chronic rhinosinusitis patients with nasal polyps and their correlation to tissue's cellularity and disease relapsing
por: Anselmo-Lima, Wilma T, et al.
Publicado: (2013)

Computational fluid dynamic modeling of the effect of dupilumab in the management of anosmia secondary to chronic rhinosinusitis with nasal polyps (CRSwNP)
por: Lepley, Thomas J., et al.
Publicado: (2022)

Symptoms of chronic rhinosinusitis with and without nasal polyps
por: Dietz de Loos, Dirk, et al.
Publicado: (2013)

Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps
por: Avdeeva, Klementina, et al.
Publicado: (2018)

Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps
por: Bachert, Claus, et al.
Publicado: (2021)

The Role of Biologics in Chronic Rhinosinusitis With Nasal Polyps
por: Patel, Gayatri B., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2ops9htm8ug95nj1diafikp4ee