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Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway

This cross-sectional study of the general population of Telemark County, Norway, aimed to identify risk factors associated with poor asthma control as defined by the Asthma Control Test (ACT), and to determine the proportions of patients with poorly controlled asthma who had undergone spirometry, us...

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Autores principales: Abrahamsen, Regine, Gundersen, Gølin Finckenhagen, Svendsen, Martin Veel, Klepaker, Geir, Kongerud, Johny, Fell, Anne Kristin Møller
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217450/
https://www.ncbi.nlm.nih.gov/pubmed/32396562
http://dx.doi.org/10.1371/journal.pone.0232621
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author Abrahamsen, Regine
Gundersen, Gølin Finckenhagen
Svendsen, Martin Veel
Klepaker, Geir
Kongerud, Johny
Fell, Anne Kristin Møller
author_facet Abrahamsen, Regine
Gundersen, Gølin Finckenhagen
Svendsen, Martin Veel
Klepaker, Geir
Kongerud, Johny
Fell, Anne Kristin Møller
author_sort Abrahamsen, Regine
collection PubMed
description This cross-sectional study of the general population of Telemark County, Norway, aimed to identify risk factors associated with poor asthma control as defined by the Asthma Control Test (ACT), and to determine the proportions of patients with poorly controlled asthma who had undergone spirometry, used asthma medication, or been examined by a pulmonary physician. In 2014–2015, the study recruited 326 subjects aged 16–50 years who had self-reported physician-diagnosed asthma and presence of respiratory symptoms during the previous 12 months. The clinical outcome measures were body mass index (BMI), forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)), fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE) in serum and serum C-reactive protein (CRP). An ACT score ≤ 19 was defined as poorly controlled asthma. Overall, 113 subjects (35%) reported poor asthma control. The odds ratios (ORs) and 95% confidence intervals (CIs) for factors associated with poorly controlled asthma were: self-reported occupational exposure to vapor, gas, dust, or fumes during the previous 12 months (OR 2.0; 95% CI 1.1–3.6), body mass index ≥ 30 kg/m(2) (OR 2.2; 95% CI 1.2–4.1), female sex (OR 2.6; 95% CI 1.5–4.7), current smoking (OR 2.8; 95% CI 1.5–5.3), and past smoking (OR 2.3; 95% CI 1.3–4.0). Poor asthma control was also associated with reduced FEV(1) after bronchodilation (β –3.6; 95% CI –7.0 to –0.2). Moreover, 13% of the participants with poor asthma control reported no use of asthma medication, 51% had not been assessed by a pulmonary physician, and 20% had never undergone spirometry. Because these data are cross-sectional, further studies assessing possible risk factors in general and objectively measured occupational exposure in particular are needed. However, our results suggest that there is room for improvement with regards to use of spirometry and pulmonary physician referrals when a patient’s asthma is inadequately controlled.
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spelling pubmed-72174502020-05-29 Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway Abrahamsen, Regine Gundersen, Gølin Finckenhagen Svendsen, Martin Veel Klepaker, Geir Kongerud, Johny Fell, Anne Kristin Møller PLoS One Research Article This cross-sectional study of the general population of Telemark County, Norway, aimed to identify risk factors associated with poor asthma control as defined by the Asthma Control Test (ACT), and to determine the proportions of patients with poorly controlled asthma who had undergone spirometry, used asthma medication, or been examined by a pulmonary physician. In 2014–2015, the study recruited 326 subjects aged 16–50 years who had self-reported physician-diagnosed asthma and presence of respiratory symptoms during the previous 12 months. The clinical outcome measures were body mass index (BMI), forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)), fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE) in serum and serum C-reactive protein (CRP). An ACT score ≤ 19 was defined as poorly controlled asthma. Overall, 113 subjects (35%) reported poor asthma control. The odds ratios (ORs) and 95% confidence intervals (CIs) for factors associated with poorly controlled asthma were: self-reported occupational exposure to vapor, gas, dust, or fumes during the previous 12 months (OR 2.0; 95% CI 1.1–3.6), body mass index ≥ 30 kg/m(2) (OR 2.2; 95% CI 1.2–4.1), female sex (OR 2.6; 95% CI 1.5–4.7), current smoking (OR 2.8; 95% CI 1.5–5.3), and past smoking (OR 2.3; 95% CI 1.3–4.0). Poor asthma control was also associated with reduced FEV(1) after bronchodilation (β –3.6; 95% CI –7.0 to –0.2). Moreover, 13% of the participants with poor asthma control reported no use of asthma medication, 51% had not been assessed by a pulmonary physician, and 20% had never undergone spirometry. Because these data are cross-sectional, further studies assessing possible risk factors in general and objectively measured occupational exposure in particular are needed. However, our results suggest that there is room for improvement with regards to use of spirometry and pulmonary physician referrals when a patient’s asthma is inadequately controlled. Public Library of Science 2020-05-12 /pmc/articles/PMC7217450/ /pubmed/32396562 http://dx.doi.org/10.1371/journal.pone.0232621 Text en © 2020 Abrahamsen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abrahamsen, Regine
Gundersen, Gølin Finckenhagen
Svendsen, Martin Veel
Klepaker, Geir
Kongerud, Johny
Fell, Anne Kristin Møller
Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway
title Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway
title_full Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway
title_fullStr Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway
title_full_unstemmed Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway
title_short Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway
title_sort possible risk factors for poor asthma control assessed in a cross-sectional population-based study from telemark, norway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217450/
https://www.ncbi.nlm.nih.gov/pubmed/32396562
http://dx.doi.org/10.1371/journal.pone.0232621
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