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Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection

Ehrlichia chaffeensis (E. chaffeensis) exploits evolutionarily conserved Notch and Wnt host cell signaling pathways to downregulate innate immune host defenses and promote infection. The multifunctional E. chaffeensis TRP120 effector which has HECT E3 ubiquitin ligase activity, interacts with the ho...

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Detalles Bibliográficos
Autores principales:	Wang, Jennifer Y., Zhu, Bing, Patterson, LaNisha L., Rogan, Madison R., Kibler, Clayton E., McBride, Jere W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217479/ https://www.ncbi.nlm.nih.gov/pubmed/32353058 http://dx.doi.org/10.1371/journal.ppat.1008541

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