Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis

BACKGROUND: Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the interaction between cancer cells and stromal pancreatic stellate cells (PSCs). This study assessed the effect of HGF/c-MET inh...

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Detalles Bibliográficos
Autores principales: Xu, Zhihong, Pang, Tony C. Y., Liu, Adele C., Pothula, Srinivasa P., Mekapogu, Alpha Raj, Perera, Chamini J., Murakami, Takashi, Goldstein, David, Pirola, Romano C., Wilson, Jeremy S., Apte, Minoti V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217847/
https://www.ncbi.nlm.nih.gov/pubmed/32203220
http://dx.doi.org/10.1038/s41416-020-0782-1

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