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Detection of low-frequency resistance-mediating SNPs in next-generation sequencing data of Mycobacterium tuberculosis complex strains with binoSNP

Accurate drug resistance detection is key for guiding effective tuberculosis treatment. While genotypic resistance can be rapidly detected by molecular methods, their application is challenged by mixed mycobacterial populations comprising both susceptible and resistant cells (heteroresistance). For...

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Detalles Bibliográficos
Autores principales:	Dreyer, Viola, Utpatel, Christian, Kohl, Thomas A., Barilar, Ivan, Gröschel, Matthias I., Feuerriegel, Silke, Niemann, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217866/ https://www.ncbi.nlm.nih.gov/pubmed/32398743 http://dx.doi.org/10.1038/s41598-020-64708-8

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