Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression

The Western diet contains a high ratio of omega-6 (ω6) to omega-3 (ω3) polyunsaturated fatty acids (PUFA). The prototypical aryl hydrocarbon receptor (AHR) ligand, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), induces CYP1 family enzymes, which can metabolize PUFA to epoxides. Mice fed ω3-rich or ω6-r...

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Detalles Bibliográficos
Autores principales: Huerta-Yepez, Sara, Tirado-Rodriguez, Ana, Montecillo-Aguado, Mayra R., Yang, Jun, Hammock, Bruce D., Hankinson, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217871/
https://www.ncbi.nlm.nih.gov/pubmed/32398692
http://dx.doi.org/10.1038/s41598-020-64146-6

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