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Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability

Oscillatory activity in the µ-frequency band (8–13 Hz) determines excitability in sensorimotor cortex. In humans, the primary motor cortex (M1) in the two hemispheres shows significant anatomical, connectional, and electrophysiological differences associated with motor dominance. It is currently unc...

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Autores principales: Stefanou, Maria-Ioanna, Galevska, Dragana, Zrenner, Christoph, Ziemann, Ulf, Nieminen, Jaakko O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217936/
https://www.ncbi.nlm.nih.gov/pubmed/32398713
http://dx.doi.org/10.1038/s41598-020-64390-w
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author Stefanou, Maria-Ioanna
Galevska, Dragana
Zrenner, Christoph
Ziemann, Ulf
Nieminen, Jaakko O.
author_facet Stefanou, Maria-Ioanna
Galevska, Dragana
Zrenner, Christoph
Ziemann, Ulf
Nieminen, Jaakko O.
author_sort Stefanou, Maria-Ioanna
collection PubMed
description Oscillatory activity in the µ-frequency band (8–13 Hz) determines excitability in sensorimotor cortex. In humans, the primary motor cortex (M1) in the two hemispheres shows significant anatomical, connectional, and electrophysiological differences associated with motor dominance. It is currently unclear whether the µ-oscillation phase effects on corticospinal excitability demonstrated previously for the motor-dominant M1 are also different between motor-dominant and motor-non-dominant M1 or, alternatively, are similar to reflect a ubiquitous physiological trait of the motor system at rest. Here, we applied single-pulse transcranial magnetic stimulation to the hand representations of the motor-dominant and the motor-non-dominant M1 of 51 healthy right-handed volunteers when electroencephalography indicated a certain µ-oscillation phase (positive peak, negative peak, or random). We determined resting motor threshold (RMT) as a marker of corticospinal excitability in the three µ-phase conditions. RMT differed significantly depending on the pre-stimulus phase of the µ-oscillation in both M1, with highest RMT in the positive-peak condition, and lowest RMT in the negative-peak condition. µ-phase-dependency of RMT correlated directly between the two M1, and interhemispheric differences in µ-phase-dependency were absent. In conclusion, µ-phase-dependency of corticospinal excitability appears to be a ubiquitous physiological trait of the motor system at rest, without hemispheric dominance.
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spelling pubmed-72179362020-05-19 Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability Stefanou, Maria-Ioanna Galevska, Dragana Zrenner, Christoph Ziemann, Ulf Nieminen, Jaakko O. Sci Rep Article Oscillatory activity in the µ-frequency band (8–13 Hz) determines excitability in sensorimotor cortex. In humans, the primary motor cortex (M1) in the two hemispheres shows significant anatomical, connectional, and electrophysiological differences associated with motor dominance. It is currently unclear whether the µ-oscillation phase effects on corticospinal excitability demonstrated previously for the motor-dominant M1 are also different between motor-dominant and motor-non-dominant M1 or, alternatively, are similar to reflect a ubiquitous physiological trait of the motor system at rest. Here, we applied single-pulse transcranial magnetic stimulation to the hand representations of the motor-dominant and the motor-non-dominant M1 of 51 healthy right-handed volunteers when electroencephalography indicated a certain µ-oscillation phase (positive peak, negative peak, or random). We determined resting motor threshold (RMT) as a marker of corticospinal excitability in the three µ-phase conditions. RMT differed significantly depending on the pre-stimulus phase of the µ-oscillation in both M1, with highest RMT in the positive-peak condition, and lowest RMT in the negative-peak condition. µ-phase-dependency of RMT correlated directly between the two M1, and interhemispheric differences in µ-phase-dependency were absent. In conclusion, µ-phase-dependency of corticospinal excitability appears to be a ubiquitous physiological trait of the motor system at rest, without hemispheric dominance. Nature Publishing Group UK 2020-05-12 /pmc/articles/PMC7217936/ /pubmed/32398713 http://dx.doi.org/10.1038/s41598-020-64390-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Stefanou, Maria-Ioanna
Galevska, Dragana
Zrenner, Christoph
Ziemann, Ulf
Nieminen, Jaakko O.
Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability
title Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability
title_full Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability
title_fullStr Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability
title_full_unstemmed Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability
title_short Interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability
title_sort interhemispheric symmetry of µ-rhythm phase-dependency of corticospinal excitability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217936/
https://www.ncbi.nlm.nih.gov/pubmed/32398713
http://dx.doi.org/10.1038/s41598-020-64390-w
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