MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

Despite growing awareness of the biologic features underlying MLL-rearranged leukemia, targeted therapies for this leukemia have remained elusive and clinical outcomes remain dismal. MBNL1, a protein involved in alternative splicing, is consistently overexpressed in MLL-rearranged leukemias. We foun...

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Detalles Bibliográficos
Autores principales: Itskovich, Svetlana S., Gurunathan, Arun, Clark, Jason, Burwinkel, Matthew, Wunderlich, Mark, Berger, Mikaela R., Kulkarni, Aishwarya, Chetal, Kashish, Venkatasubramanian, Meenakshi, Salomonis, Nathan, Kumar, Ashish R., Lee, Lynn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217953/
https://www.ncbi.nlm.nih.gov/pubmed/32398749
http://dx.doi.org/10.1038/s41467-020-15733-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217953/
https://www.ncbi.nlm.nih.gov/pubmed/32398749
http://dx.doi.org/10.1038/s41467-020-15733-8

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