Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility

Synthetic lethal screens have the potential to identify new vulnerabilities incurred by specific cancer mutations but have been hindered by lack of agreement between studies. In the case of KRAS, we identify that published synthetic lethal screen hits significantly overlap at the pathway rather than...

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Detalles Bibliográficos
Autores principales: Ku, Angel A., Hu, Hsien-Ming, Zhao, Xin, Shah, Khyati N., Kongara, Sameera, Wu, Di, McCormick, Frank, Balmain, Allan, Bandyopadhyay, Sourav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217969/
https://www.ncbi.nlm.nih.gov/pubmed/32398776
http://dx.doi.org/10.1038/s41467-020-16078-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217969/
https://www.ncbi.nlm.nih.gov/pubmed/32398776
http://dx.doi.org/10.1038/s41467-020-16078-y

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