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Junctional Neural Tube Defect

Junctional neurulation represents the most recent adjunct to the well-known sequential embryological processes of primary and secondary neurulation. While its exact molecular processes, occurring at the end of primary and the beginning of secondary neurulation, are still being actively investigated,...

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Detalles Bibliográficos
Autores principales: Eibach, Sebastian, Pang, Dachling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurosurgical Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218194/
https://www.ncbi.nlm.nih.gov/pubmed/32336064
http://dx.doi.org/10.3340/jkns.2020.0018
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author Eibach, Sebastian
Pang, Dachling
author_facet Eibach, Sebastian
Pang, Dachling
author_sort Eibach, Sebastian
collection PubMed
description Junctional neurulation represents the most recent adjunct to the well-known sequential embryological processes of primary and secondary neurulation. While its exact molecular processes, occurring at the end of primary and the beginning of secondary neurulation, are still being actively investigated, its pathological counterpart –junctional neural tube defect (JNTD)– had been described in 2017 based on three patients whose well-formed secondary neural tube, the conus, is widely separated from its corresponding primary neural tube and functionally disconnected from corticospinal control from above. Several other cases conforming to this bizarre neural tube arrangement have since appeared in the literature, reinforcing the validity of this entity. The cardinal clinical, neuroimaging, and electrophysiological features of JNTD, and the hypothesis of its embryogenetic mechanism, form part of this review.
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spelling pubmed-72181942020-05-28 Junctional Neural Tube Defect Eibach, Sebastian Pang, Dachling J Korean Neurosurg Soc Review Article Junctional neurulation represents the most recent adjunct to the well-known sequential embryological processes of primary and secondary neurulation. While its exact molecular processes, occurring at the end of primary and the beginning of secondary neurulation, are still being actively investigated, its pathological counterpart –junctional neural tube defect (JNTD)– had been described in 2017 based on three patients whose well-formed secondary neural tube, the conus, is widely separated from its corresponding primary neural tube and functionally disconnected from corticospinal control from above. Several other cases conforming to this bizarre neural tube arrangement have since appeared in the literature, reinforcing the validity of this entity. The cardinal clinical, neuroimaging, and electrophysiological features of JNTD, and the hypothesis of its embryogenetic mechanism, form part of this review. Korean Neurosurgical Society 2020-05 2020-04-27 /pmc/articles/PMC7218194/ /pubmed/32336064 http://dx.doi.org/10.3340/jkns.2020.0018 Text en Copyright © 2020 The Korean Neurosurgical Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Eibach, Sebastian
Pang, Dachling
Junctional Neural Tube Defect
title Junctional Neural Tube Defect
title_full Junctional Neural Tube Defect
title_fullStr Junctional Neural Tube Defect
title_full_unstemmed Junctional Neural Tube Defect
title_short Junctional Neural Tube Defect
title_sort junctional neural tube defect
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218194/
https://www.ncbi.nlm.nih.gov/pubmed/32336064
http://dx.doi.org/10.3340/jkns.2020.0018
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