Translational Feasibility of Lumbar Puncture for Intrathecal AAV Administration

Preclinical studies have demonstrated that a single injection of an adeno-associated virus (AAV) vector into the cerebrospinal fluid (CSF) can achieve widespread gene transfer throughout the central nervous system. Successfully translating this approach to humans requires identifying factors that in...

Descripción completa

Detalles Bibliográficos
Autores principales: Hinderer, Christian, Katz, Nathan, Dyer, Cecilia, Goode, Tamara, Johansson, Julia, Bell, Peter, Richman, Laura, Buza, Elizabeth, Wilson, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218226/
https://www.ncbi.nlm.nih.gov/pubmed/32420410
http://dx.doi.org/10.1016/j.omtm.2020.04.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218226/
https://www.ncbi.nlm.nih.gov/pubmed/32420410
http://dx.doi.org/10.1016/j.omtm.2020.04.012

Ejemplares similares