Cargando…
Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4
Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer. Importantly, our recent work examining metastatic biopsy samples demonstrates NEPC is increasing in frequency. In contrast to prostate adenocarcinomas that express a luminal gene expression program, NEPC tumors expre...
Autores principales: | Coleman, Daniel J., Sampson, David A., Sehrawat, Archana, Kumaraswamy, Anbarasu, Sun, Duanchen, Wang, Yuzhuo, Schwartzman, Jacob, Urrutia, Joshua, Lee, Ahn R., Coleman, Ilsa M., Nelson, Peter S., Dong, Xuesen, Morrissey, Colm, Corey, Eva, Xia, Zheng, Yates, Joel A., Alumkal, Joshi J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218227/ https://www.ncbi.nlm.nih.gov/pubmed/32403054 http://dx.doi.org/10.1016/j.neo.2020.04.002 |
Ejemplares similares
-
LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function
por: Kumaraswamy, Anbarasu, et al.
Publicado: (2023) -
Establishment of a neuroendocrine prostate cancer model driven by the RNA splicing factor SRRM4
por: Li, Yinan, et al.
Publicado: (2017) -
BET Bromodomain Inhibition Blocks an AR-Repressed, E2F1-Activated Treatment-Emergent Neuroendocrine Prostate Cancer Lineage Plasticity Program
por: Kim, Dae-Hwan, et al.
Publicado: (2021) -
Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer
por: Gan, Yu, et al.
Publicado: (2018) -
SRRM2 organizes splicing condensates to regulate alternative splicing
por: Xu, Shaohai, et al.
Publicado: (2022)