Novel Non-integrating DNA Nano-S/MAR Vectors Restore Gene Function in Isogenic Patient-Derived Pancreatic Tumor Models

We describe herein non-integrating minimally sized nano-S/MAR DNA vectors, which can be used to genetically modify dividing cells in place of integrating vectors. They represent a unique genetic tool, which avoids vector-mediated damage. Previous work has shown that DNA vectors comprising a mammalia...

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Detalles Bibliográficos
Autores principales: Bozza, Matthias, Green, Edward W., Espinet, Elisa, De Roia, Alice, Klein, Corinna, Vogel, Vanessa, Offringa, Rienk, Williams, James A., Sprick, Martin, Harbottle, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218229/
https://www.ncbi.nlm.nih.gov/pubmed/32420409
http://dx.doi.org/10.1016/j.omtm.2020.04.017

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