Tissue-specific effects of an anti-desmoglein-3 ADCC antibody due to expression of the target antigen and physiological characteristics of the mouse vagina

Desmoglein-3 (DSG3) is a potential target of cytotoxic antibody therapy for squamous cell carcinomas but is also expressed in various normal squamous epithelia. We obtained information about DSG3 distribution in mouse tissues by immunohistochemistry and conducted an intravenous multiple-dose study i...

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Detalles Bibliográficos
Autores principales: Fujii, Etsuko, Funahashi, Shinichi, Taniguchi, Kenji, Kawai, Shigeto, Nakano, Kiyotaka, Kato, Atsuhiko, Suzuki, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218237/
https://www.ncbi.nlm.nih.gov/pubmed/32425339
http://dx.doi.org/10.1293/tox.2019-0040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218237/
https://www.ncbi.nlm.nih.gov/pubmed/32425339
http://dx.doi.org/10.1293/tox.2019-0040

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