Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes’ toxicity

BACKGROUND: Aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of aliphatic aldehydes, including acetaldehyde. About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes. METH...

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Detalles Bibliográficos
Autores principales: Chen, Che-Hong, Ferreira, Julio C.B., Joshi, Amit U., Stevens, Matthew C., Li, Sin-Jin, Hsu, Jade H.-M., Maclean, Rory, Ferreira, Nikolas D., Cervantes, Pilar R., Martinez, Diana D., Barrientos, Fernando L., Quintanares, Gibran H.R., Mochly-Rosen, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218264/
https://www.ncbi.nlm.nih.gov/pubmed/32403082
http://dx.doi.org/10.1016/j.ebiom.2020.102753

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