Cargando…

Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic

Over 200 million people are exposed to arsenic worldwide in their daily lives. Arsenic is a toxic ubiquitous metalloid distributed in the ground water. From the last few decades it is obtaining considerable attention for its severe neurotoxic properties. In this study the neuroprotective efficacy of...

Descripción completa

Detalles Bibliográficos
Autores principales: Peruru, Rupasree, Usha Rani, R., Thatiparthi, Jhansyrani, Sampathi, Sunitha, Dodoala, Sujatha, Prasad, K.V.S.R.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218267/
https://www.ncbi.nlm.nih.gov/pubmed/32420487
http://dx.doi.org/10.1016/j.heliyon.2020.e03921
_version_ 1783532764401762304
author Peruru, Rupasree
Usha Rani, R.
Thatiparthi, Jhansyrani
Sampathi, Sunitha
Dodoala, Sujatha
Prasad, K.V.S.R.G.
author_facet Peruru, Rupasree
Usha Rani, R.
Thatiparthi, Jhansyrani
Sampathi, Sunitha
Dodoala, Sujatha
Prasad, K.V.S.R.G.
author_sort Peruru, Rupasree
collection PubMed
description Over 200 million people are exposed to arsenic worldwide in their daily lives. Arsenic is a toxic ubiquitous metalloid distributed in the ground water. From the last few decades it is obtaining considerable attention for its severe neurotoxic properties. In this study the neuroprotective efficacy of devil's claw (DCW), a potent antioxidant has been investigated against arsenic induced neurotoxicity in female rats. Neurotoxicity was established by oral administration of 13 mg/kg sodium arsenite. The animals were divided into five groups (n = 6) including normal control, disease/arsenic control, standard treatment (Apocynin, 10 mg/kg), DCW treatment I (DCW, 200 mg/kg) and DCW treatment II (DCW, 400 mg/kg). Exploratory, anxiety and motor coordination related behavior of the animals was assessed using hole-board, forced swimming, beam walk and elevated plus maze tests. Findings revealed that DCW treatment ameliorated anxiety and motor in-coordination in the rats compared to the arsenic control group. In addition, arsenic induced a significant oxidative stress in arsenic only treated group, whereas co-administration with DCW the oxidative stress was reduced prominently. Arsenic control group produced gliosis and nuclear pyknosis of the brain cells which were prominently suppressed with the treatment of DCW for 21 days. The activity of DCW was in correlation with the concentration of harpagoside in the serum estimated by the HPLC method, supports that harpagoside was the active constituent responsible for neuroprotective effect. Further findings are required to understand the molecular mechanisms involved in neuroprotective effect of harpagoside and DCW.
format Online
Article
Text
id pubmed-7218267
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-72182672020-05-15 Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic Peruru, Rupasree Usha Rani, R. Thatiparthi, Jhansyrani Sampathi, Sunitha Dodoala, Sujatha Prasad, K.V.S.R.G. Heliyon Article Over 200 million people are exposed to arsenic worldwide in their daily lives. Arsenic is a toxic ubiquitous metalloid distributed in the ground water. From the last few decades it is obtaining considerable attention for its severe neurotoxic properties. In this study the neuroprotective efficacy of devil's claw (DCW), a potent antioxidant has been investigated against arsenic induced neurotoxicity in female rats. Neurotoxicity was established by oral administration of 13 mg/kg sodium arsenite. The animals were divided into five groups (n = 6) including normal control, disease/arsenic control, standard treatment (Apocynin, 10 mg/kg), DCW treatment I (DCW, 200 mg/kg) and DCW treatment II (DCW, 400 mg/kg). Exploratory, anxiety and motor coordination related behavior of the animals was assessed using hole-board, forced swimming, beam walk and elevated plus maze tests. Findings revealed that DCW treatment ameliorated anxiety and motor in-coordination in the rats compared to the arsenic control group. In addition, arsenic induced a significant oxidative stress in arsenic only treated group, whereas co-administration with DCW the oxidative stress was reduced prominently. Arsenic control group produced gliosis and nuclear pyknosis of the brain cells which were prominently suppressed with the treatment of DCW for 21 days. The activity of DCW was in correlation with the concentration of harpagoside in the serum estimated by the HPLC method, supports that harpagoside was the active constituent responsible for neuroprotective effect. Further findings are required to understand the molecular mechanisms involved in neuroprotective effect of harpagoside and DCW. Elsevier 2020-05-08 /pmc/articles/PMC7218267/ /pubmed/32420487 http://dx.doi.org/10.1016/j.heliyon.2020.e03921 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Peruru, Rupasree
Usha Rani, R.
Thatiparthi, Jhansyrani
Sampathi, Sunitha
Dodoala, Sujatha
Prasad, K.V.S.R.G.
Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic
title Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic
title_full Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic
title_fullStr Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic
title_full_unstemmed Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic
title_short Devil's claw (Harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic
title_sort devil's claw (harpagophytum procumbens) ameliorates the neurobehavioral changes and neurotoxicity in female rats exposed to arsenic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218267/
https://www.ncbi.nlm.nih.gov/pubmed/32420487
http://dx.doi.org/10.1016/j.heliyon.2020.e03921
work_keys_str_mv AT perururupasree devilsclawharpagophytumprocumbensamelioratestheneurobehavioralchangesandneurotoxicityinfemaleratsexposedtoarsenic
AT usharanir devilsclawharpagophytumprocumbensamelioratestheneurobehavioralchangesandneurotoxicityinfemaleratsexposedtoarsenic
AT thatiparthijhansyrani devilsclawharpagophytumprocumbensamelioratestheneurobehavioralchangesandneurotoxicityinfemaleratsexposedtoarsenic
AT sampathisunitha devilsclawharpagophytumprocumbensamelioratestheneurobehavioralchangesandneurotoxicityinfemaleratsexposedtoarsenic
AT dodoalasujatha devilsclawharpagophytumprocumbensamelioratestheneurobehavioralchangesandneurotoxicityinfemaleratsexposedtoarsenic
AT prasadkvsrg devilsclawharpagophytumprocumbensamelioratestheneurobehavioralchangesandneurotoxicityinfemaleratsexposedtoarsenic