A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and heal...

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Detalles Bibliográficos
Autores principales: Casanova, Jean-Laurent, Su, Helen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218368/
https://www.ncbi.nlm.nih.gov/pubmed/32405102
http://dx.doi.org/10.1016/j.cell.2020.05.016
Descripción
Sumario:SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.

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