A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and heal...

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Detalles Bibliográficos
Autores principales: Casanova, Jean-Laurent, Su, Helen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218368/
https://www.ncbi.nlm.nih.gov/pubmed/32405102
http://dx.doi.org/10.1016/j.cell.2020.05.016
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author Casanova, Jean-Laurent
Su, Helen C.
author_facet Casanova, Jean-Laurent
Su, Helen C.
author_sort Casanova, Jean-Laurent
collection PubMed
description SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.
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spelling pubmed-72183682020-05-13 A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection Casanova, Jean-Laurent Su, Helen C. Cell Commentary SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease. Elsevier Inc. 2020-06-11 2020-05-13 /pmc/articles/PMC7218368/ /pubmed/32405102 http://dx.doi.org/10.1016/j.cell.2020.05.016 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Commentary
Casanova, Jean-Laurent
Su, Helen C.
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
title A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
title_full A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
title_fullStr A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
title_full_unstemmed A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
title_short A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
title_sort global effort to define the human genetics of protective immunity to sars-cov-2 infection
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218368/
https://www.ncbi.nlm.nih.gov/pubmed/32405102
http://dx.doi.org/10.1016/j.cell.2020.05.016
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