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A model based study on the dynamics of COVID-19: Prediction and control

As there is no vaccination and proper medicine for treatment, the recent pandemic caused by COVID-19 has drawn attention to the strategies of quarantine and other governmental measures, like lockdown, media coverage on social isolation, and improvement of public hygiene, etc to control the disease....

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Autores principales: Mandal, Manotosh, Jana, Soovoojeet, Nandi, Swapan Kumar, Khatua, Anupam, Adak, Sayani, Kar, T.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218394/
https://www.ncbi.nlm.nih.gov/pubmed/32406395
http://dx.doi.org/10.1016/j.chaos.2020.109889
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author Mandal, Manotosh
Jana, Soovoojeet
Nandi, Swapan Kumar
Khatua, Anupam
Adak, Sayani
Kar, T.K.
author_facet Mandal, Manotosh
Jana, Soovoojeet
Nandi, Swapan Kumar
Khatua, Anupam
Adak, Sayani
Kar, T.K.
author_sort Mandal, Manotosh
collection PubMed
description As there is no vaccination and proper medicine for treatment, the recent pandemic caused by COVID-19 has drawn attention to the strategies of quarantine and other governmental measures, like lockdown, media coverage on social isolation, and improvement of public hygiene, etc to control the disease. The mathematical model can help when these intervention measures are the best strategies for disease control as well as how they might affect the disease dynamics. Motivated by this, in this article, we have formulated a mathematical model introducing a quarantine class and governmental intervention measures to mitigate disease transmission. We study a thorough dynamical behavior of the model in terms of the basic reproduction number. Further, we perform the sensitivity analysis of the essential reproduction number and found that reducing the contact of exposed and susceptible humans is the most critical factor in achieving disease control. To lessen the infected individuals as well as to minimize the cost of implementing government control measures, we formulate an optimal control problem, and optimal control is determined. Finally, we forecast a short-term trend of COVID-19 for the three highly affected states, Maharashtra, Delhi, and Tamil Nadu, in India, and it suggests that the first two states need further monitoring of control measures to reduce the contact of exposed and susceptible humans.
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spelling pubmed-72183942020-05-13 A model based study on the dynamics of COVID-19: Prediction and control Mandal, Manotosh Jana, Soovoojeet Nandi, Swapan Kumar Khatua, Anupam Adak, Sayani Kar, T.K. Chaos Solitons Fractals Article As there is no vaccination and proper medicine for treatment, the recent pandemic caused by COVID-19 has drawn attention to the strategies of quarantine and other governmental measures, like lockdown, media coverage on social isolation, and improvement of public hygiene, etc to control the disease. The mathematical model can help when these intervention measures are the best strategies for disease control as well as how they might affect the disease dynamics. Motivated by this, in this article, we have formulated a mathematical model introducing a quarantine class and governmental intervention measures to mitigate disease transmission. We study a thorough dynamical behavior of the model in terms of the basic reproduction number. Further, we perform the sensitivity analysis of the essential reproduction number and found that reducing the contact of exposed and susceptible humans is the most critical factor in achieving disease control. To lessen the infected individuals as well as to minimize the cost of implementing government control measures, we formulate an optimal control problem, and optimal control is determined. Finally, we forecast a short-term trend of COVID-19 for the three highly affected states, Maharashtra, Delhi, and Tamil Nadu, in India, and it suggests that the first two states need further monitoring of control measures to reduce the contact of exposed and susceptible humans. Elsevier Ltd. 2020-07 2020-05-13 /pmc/articles/PMC7218394/ /pubmed/32406395 http://dx.doi.org/10.1016/j.chaos.2020.109889 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mandal, Manotosh
Jana, Soovoojeet
Nandi, Swapan Kumar
Khatua, Anupam
Adak, Sayani
Kar, T.K.
A model based study on the dynamics of COVID-19: Prediction and control
title A model based study on the dynamics of COVID-19: Prediction and control
title_full A model based study on the dynamics of COVID-19: Prediction and control
title_fullStr A model based study on the dynamics of COVID-19: Prediction and control
title_full_unstemmed A model based study on the dynamics of COVID-19: Prediction and control
title_short A model based study on the dynamics of COVID-19: Prediction and control
title_sort model based study on the dynamics of covid-19: prediction and control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218394/
https://www.ncbi.nlm.nih.gov/pubmed/32406395
http://dx.doi.org/10.1016/j.chaos.2020.109889
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