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Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study

OBJECTIVES: To evaluate the association between proteinuria and maternal and neonatal outcomes in pregnant women with pre-eclampsia. METHODS: This retrospective study included patients beyond 20 weeks of gestation diagnosed with pre-eclampsia, who were admitted to Suzhou Municipal Hospital between D...

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Autores principales: Xu, Xiangxiang, Wang, Yun, Xu, Hui, Kang, Yan, Zhu, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218474/
https://www.ncbi.nlm.nih.gov/pubmed/32339047
http://dx.doi.org/10.1177/0300060520908114
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author Xu, Xiangxiang
Wang, Yun
Xu, Hui
Kang, Yan
Zhu, Qin
author_facet Xu, Xiangxiang
Wang, Yun
Xu, Hui
Kang, Yan
Zhu, Qin
author_sort Xu, Xiangxiang
collection PubMed
description OBJECTIVES: To evaluate the association between proteinuria and maternal and neonatal outcomes in pregnant women with pre-eclampsia. METHODS: This retrospective study included patients beyond 20 weeks of gestation diagnosed with pre-eclampsia, who were admitted to Suzhou Municipal Hospital between December 2013 and December 2015. Demographic and clinical data were extracted from clinical records, including age, body mass index, newborn weight and Apgar score. Pre-eclampsia risk factors and perinatal outcomes were analysed. RESULTS: A total of 407 patients were enrolled, of whom, 402 with pre-eclampsia were included in the final analyses, divided into two groups: patients with proteinuria (n = 364 [90.55%]) and patients without proteinuria (n = 38 [9.45%]). Newborn 5-min Apgar scores were statistically lower in the proteinuria group versus the group without proteinuria (9.77 versus 9.95). Compared with patients without proteinuria, patients with proteinuria had a significantly higher rate of births before 37 weeks of gestation (50.80% versus 31.60%), but the incidence of preterm membrane rupture was significantly lower (3.8% versus 13.2%). CONCLUSION: Proteinuria may be associated with adverse maternal and neonatal outcomes in cases of pre-eclampsia.
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spelling pubmed-72184742020-05-18 Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study Xu, Xiangxiang Wang, Yun Xu, Hui Kang, Yan Zhu, Qin J Int Med Res Retrospective Clinical Research Report OBJECTIVES: To evaluate the association between proteinuria and maternal and neonatal outcomes in pregnant women with pre-eclampsia. METHODS: This retrospective study included patients beyond 20 weeks of gestation diagnosed with pre-eclampsia, who were admitted to Suzhou Municipal Hospital between December 2013 and December 2015. Demographic and clinical data were extracted from clinical records, including age, body mass index, newborn weight and Apgar score. Pre-eclampsia risk factors and perinatal outcomes were analysed. RESULTS: A total of 407 patients were enrolled, of whom, 402 with pre-eclampsia were included in the final analyses, divided into two groups: patients with proteinuria (n = 364 [90.55%]) and patients without proteinuria (n = 38 [9.45%]). Newborn 5-min Apgar scores were statistically lower in the proteinuria group versus the group without proteinuria (9.77 versus 9.95). Compared with patients without proteinuria, patients with proteinuria had a significantly higher rate of births before 37 weeks of gestation (50.80% versus 31.60%), but the incidence of preterm membrane rupture was significantly lower (3.8% versus 13.2%). CONCLUSION: Proteinuria may be associated with adverse maternal and neonatal outcomes in cases of pre-eclampsia. SAGE Publications 2020-04-27 /pmc/articles/PMC7218474/ /pubmed/32339047 http://dx.doi.org/10.1177/0300060520908114 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Xu, Xiangxiang
Wang, Yun
Xu, Hui
Kang, Yan
Zhu, Qin
Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study
title Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study
title_full Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study
title_fullStr Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study
title_full_unstemmed Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study
title_short Association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study
title_sort association between proteinuria and maternal and neonatal outcomes in pre-eclampsia pregnancy: a retrospective observational study
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218474/
https://www.ncbi.nlm.nih.gov/pubmed/32339047
http://dx.doi.org/10.1177/0300060520908114
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