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Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial
BACKGROUND: High FiO(2) during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E(1) (PGE(1)) can improve oxygenation and attenuate oxidative stress during OLV under a lower FiO(2...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218546/ https://www.ncbi.nlm.nih.gov/pubmed/32404117 http://dx.doi.org/10.1186/s12931-020-01380-6 |
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author | Li, Pengyi Gu, Lianbing Bian, Qingming Tan, Jing Jiao, Dian Wu, Fei Xu, Zeping Wang, Lijun |
author_facet | Li, Pengyi Gu, Lianbing Bian, Qingming Tan, Jing Jiao, Dian Wu, Fei Xu, Zeping Wang, Lijun |
author_sort | Li, Pengyi |
collection | PubMed |
description | BACKGROUND: High FiO(2) during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E(1) (PGE(1)) can improve oxygenation and attenuate oxidative stress during OLV under a lower FiO(2). METHOD: Ninety patients selectively undergoing thoracotomy for esophageal cancer were randomly divided into three groups (n = 30/group): Group P (FiO(2) = 0.6, inhaling PGE(1) 0.1 μg/kg), Group L (FiO(2) = 0.6) and Group C (FiO(2) = 1.0). The primary outcomes were oxygenation and pulmonary shunt during OLV. Secondary outcomes included haemodynamics, respiratory mechanics and oxidative stress in serum. RESULTS: Patients in Group P had significantly higher PaO(2) and lower shunt fraction in 30 min of OLV compared with Group L. Compared with Group C, patients in Group P had similar levels of PaO(2)/FiO(2) in 60 min and higher levels of PaO(2)/FiO(2) at 2 h during OLV. The levels of PvO(2) and SvO(2) in Group P and Group L were significantly lower than Group C. Patients in Group P and Group L had significantly higher levels of superoxide dismutase and lower levels of malondialdehyde than Group C. No significant differences were found in SPO(2), ETCO(2), PaCO(2), Paw, HR and MAP among the three groups. The complications in Group C were significantly higher than another two groups. CONCLUSION: PGE(1) can maintain adequate oxygenation in patients with low FiO(2) (0.6) during OLV. Reducing FiO(2) to 0.6 during OLV can decrease the levels of oxidative stress and complications after OLV. TRIAL REGISTRATION: chictr.org.cn identifier: ChiCTR1800017100. |
format | Online Article Text |
id | pubmed-7218546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72185462020-05-18 Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial Li, Pengyi Gu, Lianbing Bian, Qingming Tan, Jing Jiao, Dian Wu, Fei Xu, Zeping Wang, Lijun Respir Res Research BACKGROUND: High FiO(2) during one-lung ventilation (OLV) can improve oxygenation, but increase the risk of atelectasis and oxidative stress. The aim of this study was to analyze whether Prostaglandin E(1) (PGE(1)) can improve oxygenation and attenuate oxidative stress during OLV under a lower FiO(2). METHOD: Ninety patients selectively undergoing thoracotomy for esophageal cancer were randomly divided into three groups (n = 30/group): Group P (FiO(2) = 0.6, inhaling PGE(1) 0.1 μg/kg), Group L (FiO(2) = 0.6) and Group C (FiO(2) = 1.0). The primary outcomes were oxygenation and pulmonary shunt during OLV. Secondary outcomes included haemodynamics, respiratory mechanics and oxidative stress in serum. RESULTS: Patients in Group P had significantly higher PaO(2) and lower shunt fraction in 30 min of OLV compared with Group L. Compared with Group C, patients in Group P had similar levels of PaO(2)/FiO(2) in 60 min and higher levels of PaO(2)/FiO(2) at 2 h during OLV. The levels of PvO(2) and SvO(2) in Group P and Group L were significantly lower than Group C. Patients in Group P and Group L had significantly higher levels of superoxide dismutase and lower levels of malondialdehyde than Group C. No significant differences were found in SPO(2), ETCO(2), PaCO(2), Paw, HR and MAP among the three groups. The complications in Group C were significantly higher than another two groups. CONCLUSION: PGE(1) can maintain adequate oxygenation in patients with low FiO(2) (0.6) during OLV. Reducing FiO(2) to 0.6 during OLV can decrease the levels of oxidative stress and complications after OLV. TRIAL REGISTRATION: chictr.org.cn identifier: ChiCTR1800017100. BioMed Central 2020-05-13 2020 /pmc/articles/PMC7218546/ /pubmed/32404117 http://dx.doi.org/10.1186/s12931-020-01380-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Li, Pengyi Gu, Lianbing Bian, Qingming Tan, Jing Jiao, Dian Wu, Fei Xu, Zeping Wang, Lijun Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial |
title | Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial |
title_full | Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial |
title_fullStr | Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial |
title_full_unstemmed | Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial |
title_short | Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial |
title_sort | effects of prostaglandin e(1) nebulization of ventilated lung under 60%o(2) one lung ventilation on patients’ oxygenation and oxidative stress: a randomised controlled trial |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218546/ https://www.ncbi.nlm.nih.gov/pubmed/32404117 http://dx.doi.org/10.1186/s12931-020-01380-6 |
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