CRNDE: an oncogenic long non-coding RNA in cancers

Colorectal neoplasia differentially expressed (CRNDE) is a long non-coding RNA which has been proved upregulated in various cancers. Meanwhile, CRNDE has been demonstrated to be involved in multiple biological processes of different cancers according to previous study. Moreover, recent studies sugge...

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Detalles Bibliográficos
Autores principales: Lu, Ya, Sha, Huanhuan, Sun, Xun, Zhang, Yuan, Wu, Yang, Zhang, Junying, Zhang, Hui, Wu, Jianzhong, Feng, Jifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218640/
https://www.ncbi.nlm.nih.gov/pubmed/32435153
http://dx.doi.org/10.1186/s12935-020-01246-3
Descripción
Sumario:Colorectal neoplasia differentially expressed (CRNDE) is a long non-coding RNA which has been proved upregulated in various cancers. Meanwhile, CRNDE has been demonstrated to be involved in multiple biological processes of different cancers according to previous study. Moreover, recent studies suggested CRNDE might be a potential diagnostic biomarker and prognostic predictor due to its high sensitivity and specificity in cancer tissues and plasma. In this review, we summarize the biological function of CRNDE and the relevant mechanisms in cancers to establish a molecular basis for the clinical use of CRNDE in the future.

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