Cargando…

Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT

BACKGROUND: Aromatase inhibitors prevent the aromatization of androgens into estrogens, which reduces the negative feedback of estrogen on the hypothalamic-pituitary axis. It is clear that increasing the secretion of follicle-stimulating hormones results in an increased follicular growth. OBJECTIVE:...

Descripción completa

Detalles Bibliográficos
Autores principales: Eftekhar, Maryam, Saeed, Lida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218674/
https://www.ncbi.nlm.nih.gov/pubmed/32494767
http://dx.doi.org/10.18502/ijrm.v13i4.6891
_version_ 1783532848338173952
author Eftekhar, Maryam
Saeed, Lida
author_facet Eftekhar, Maryam
Saeed, Lida
author_sort Eftekhar, Maryam
collection PubMed
description BACKGROUND: Aromatase inhibitors prevent the aromatization of androgens into estrogens, which reduces the negative feedback of estrogen on the hypothalamic-pituitary axis. It is clear that increasing the secretion of follicle-stimulating hormones results in an increased follicular growth. OBJECTIVE: This study aimed to evaluate the effect of adding letrozole to gonadotropin on in vitro fertilization outcomes in normal responders. MATERIALS AND METHODS: In this randomized clinical trial, 100 normal responder women candidate for controlled ovarian stimulation were randomly enrolled in two groups (n = 50/each). In the case group letrozole was added to gonadotropin in the antagonist protocol. The control group received the conventional antagonist protocol. The main outcome was clinical and chemical pregnancy; and the second outcomes were the number of mature oocytes, the fertilization rate, estradiol level, and the total dose of gonadotropins. RESULTS: Basic clinical and demographic features were comparable between the groups. Estradiol level on the day of human-chorionic-gonadotropin administration and the total gonadotropin consumption were significantly higher in the control group than the case group (p = 0.045). In addition, the number of MII oocytes was higher (but not significantl) in the case group than the control group (p = 0.09). Moreover, the endometrial thickness was significantly lower in the case group. There were no significant differences in fertilization rate and chemical and clinical pregnancy rates between the two groups. CONCLUSION: Although adding letrozole to gonadotropin in normal responders reduces the total dose of gonadotropin, it does not improve the pregnancy outcomes.
format Online
Article
Text
id pubmed-7218674
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Knowledge E
record_format MEDLINE/PubMed
spelling pubmed-72186742020-06-02 Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT Eftekhar, Maryam Saeed, Lida Int J Reprod Biomed Research Article BACKGROUND: Aromatase inhibitors prevent the aromatization of androgens into estrogens, which reduces the negative feedback of estrogen on the hypothalamic-pituitary axis. It is clear that increasing the secretion of follicle-stimulating hormones results in an increased follicular growth. OBJECTIVE: This study aimed to evaluate the effect of adding letrozole to gonadotropin on in vitro fertilization outcomes in normal responders. MATERIALS AND METHODS: In this randomized clinical trial, 100 normal responder women candidate for controlled ovarian stimulation were randomly enrolled in two groups (n = 50/each). In the case group letrozole was added to gonadotropin in the antagonist protocol. The control group received the conventional antagonist protocol. The main outcome was clinical and chemical pregnancy; and the second outcomes were the number of mature oocytes, the fertilization rate, estradiol level, and the total dose of gonadotropins. RESULTS: Basic clinical and demographic features were comparable between the groups. Estradiol level on the day of human-chorionic-gonadotropin administration and the total gonadotropin consumption were significantly higher in the control group than the case group (p = 0.045). In addition, the number of MII oocytes was higher (but not significantl) in the case group than the control group (p = 0.09). Moreover, the endometrial thickness was significantly lower in the case group. There were no significant differences in fertilization rate and chemical and clinical pregnancy rates between the two groups. CONCLUSION: Although adding letrozole to gonadotropin in normal responders reduces the total dose of gonadotropin, it does not improve the pregnancy outcomes. Knowledge E 2020-04-30 /pmc/articles/PMC7218674/ /pubmed/32494767 http://dx.doi.org/10.18502/ijrm.v13i4.6891 Text en Copyright © 2020 Eftekhar et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Article
Eftekhar, Maryam
Saeed, Lida
Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
title Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
title_full Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
title_fullStr Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
title_full_unstemmed Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
title_short Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
title_sort effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: an rct
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218674/
https://www.ncbi.nlm.nih.gov/pubmed/32494767
http://dx.doi.org/10.18502/ijrm.v13i4.6891
work_keys_str_mv AT eftekharmaryam effectofaddingletrozoletogonadotropinoninvitrofertilizationoutcomesanrct
AT saeedlida effectofaddingletrozoletogonadotropinoninvitrofertilizationoutcomesanrct