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Hepatocellular carcinoma and multiple myeloma with elevated globulin: a case report and literature review
A 60-year-old male patient presented with a serum α-fetoprotein (AFP) level of 2940.5 ng/mL accompanied by a significant increase in serum globulin. Hepatitis B virus (HBV) DNA was 2.85 × 10(3) (normal value <1.0 × 10(3)). B-mode ultrasound and magnetic resonance imaging showed characteristic man...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218943/ https://www.ncbi.nlm.nih.gov/pubmed/32363985 http://dx.doi.org/10.1177/0300060520920395 |
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author | Xu, Ling Yang, Wei Shu, Ye-Fei Xu, Xiao-Feng |
author_facet | Xu, Ling Yang, Wei Shu, Ye-Fei Xu, Xiao-Feng |
author_sort | Xu, Ling |
collection | PubMed |
description | A 60-year-old male patient presented with a serum α-fetoprotein (AFP) level of 2940.5 ng/mL accompanied by a significant increase in serum globulin. Hepatitis B virus (HBV) DNA was 2.85 × 10(3) (normal value <1.0 × 10(3)). B-mode ultrasound and magnetic resonance imaging showed characteristic manifestations and he was clinically diagnosed with hepatocellular carcinoma in January 2015. He received radiofrequency ablation and tenofovir disoproxil anti-HBV therapy and his serum AFP and globulin levels were significantly reduced. In March 2018, he presented at our Hematology Department with fatigue and a pale complexion. At that time, his serum AFP level was normal, with hemoglobin 61 g/L and globulin 64.7 g/L. He was diagnosed with multiple myeloma (MM) by bone marrow examination, and immunofixation electrophoresis. The patient received PCD chemotherapy (bortezomib 2.0 g/dL on days 1, 4, 8, and 11 plus cyclophosphamide 0.3 g/dL on days 1–4 plus dexamethasone 20 mg/dL on days 1–2, 4–5, 8–9, and 11–12). The patient finally died of MM complicated by disseminated intravascular coagulation. |
format | Online Article Text |
id | pubmed-7218943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72189432020-05-20 Hepatocellular carcinoma and multiple myeloma with elevated globulin: a case report and literature review Xu, Ling Yang, Wei Shu, Ye-Fei Xu, Xiao-Feng J Int Med Res Case Report A 60-year-old male patient presented with a serum α-fetoprotein (AFP) level of 2940.5 ng/mL accompanied by a significant increase in serum globulin. Hepatitis B virus (HBV) DNA was 2.85 × 10(3) (normal value <1.0 × 10(3)). B-mode ultrasound and magnetic resonance imaging showed characteristic manifestations and he was clinically diagnosed with hepatocellular carcinoma in January 2015. He received radiofrequency ablation and tenofovir disoproxil anti-HBV therapy and his serum AFP and globulin levels were significantly reduced. In March 2018, he presented at our Hematology Department with fatigue and a pale complexion. At that time, his serum AFP level was normal, with hemoglobin 61 g/L and globulin 64.7 g/L. He was diagnosed with multiple myeloma (MM) by bone marrow examination, and immunofixation electrophoresis. The patient received PCD chemotherapy (bortezomib 2.0 g/dL on days 1, 4, 8, and 11 plus cyclophosphamide 0.3 g/dL on days 1–4 plus dexamethasone 20 mg/dL on days 1–2, 4–5, 8–9, and 11–12). The patient finally died of MM complicated by disseminated intravascular coagulation. SAGE Publications 2020-05-04 /pmc/articles/PMC7218943/ /pubmed/32363985 http://dx.doi.org/10.1177/0300060520920395 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Xu, Ling Yang, Wei Shu, Ye-Fei Xu, Xiao-Feng Hepatocellular carcinoma and multiple myeloma with elevated globulin: a case report and literature review |
title | Hepatocellular carcinoma and multiple myeloma with elevated globulin:
a case report and literature review |
title_full | Hepatocellular carcinoma and multiple myeloma with elevated globulin:
a case report and literature review |
title_fullStr | Hepatocellular carcinoma and multiple myeloma with elevated globulin:
a case report and literature review |
title_full_unstemmed | Hepatocellular carcinoma and multiple myeloma with elevated globulin:
a case report and literature review |
title_short | Hepatocellular carcinoma and multiple myeloma with elevated globulin:
a case report and literature review |
title_sort | hepatocellular carcinoma and multiple myeloma with elevated globulin:
a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218943/ https://www.ncbi.nlm.nih.gov/pubmed/32363985 http://dx.doi.org/10.1177/0300060520920395 |
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