Cargando…
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population
OBJECTIVE: To evaluate the diagnostic utility of The Bethesda System for Reporting Thyroid Cytology (TBSRTC) at Peking University Cancer Hospital, the incidence of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), and the impact of reclassification on cytopatholo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219100/ https://www.ncbi.nlm.nih.gov/pubmed/32410792 http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.02 |
_version_ | 1783532928811139072 |
---|---|
author | Zhu, Yanli Song, Yuntao Xu, Guohui Fan, Zhihui Ren, Wenhao |
author_facet | Zhu, Yanli Song, Yuntao Xu, Guohui Fan, Zhihui Ren, Wenhao |
author_sort | Zhu, Yanli |
collection | PubMed |
description | OBJECTIVE: To evaluate the diagnostic utility of The Bethesda System for Reporting Thyroid Cytology (TBSRTC) at Peking University Cancer Hospital, the incidence of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), and the impact of reclassification on cytopathological outcomes. METHODS: We performed a retrospective study of thyroid fine-needle aspiration (FNA) cases between April 2014 and March 2019. The FNA results were classified according to TBSRTC. Post-surgery histological findings were followed up. RESULTS: A total of 2,781 thyroid FNAs were performed. The incidences of the 6 diagnostic categories (DCs I−VI) were 14.8%, 17.1%, 15.8%, 2.3%, 11.6% and 38.5%, respectively. A total of 1,122 patients (40.3%) had corresponding histological results. NIFTP accounted for 0.4% of papillary thyroid carcinoma (PTC) cases, and there was no significant difference in the risk of malignancy (ROM) for each TBSRTC DC between “NIFTP=carcinoma (Ca)” and “NIFTP≠Ca”. When “NIFTP=Ca”, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of TBSRTC were 98.0%, 84.0%, 99.4%, 58.3%, and 97.5%, respectively. When “NIFTP≠Ca”, the sensitivity, specificity, PPV, NPV and accuracy of the TBSRTC were 98.1%, 81.5%, 99.3%, 61.1%, and 97.5%, respectively. CONCLUSIONS: TBSRTC is effective in the preoperative diagnosis of thyroid nodules in Peking University Cancer Hospital. The impact of the reclassification of NIFTP on cytopathological outcomes is limited because of its low incidence, and the revised ROMs are not suitable for Asian patients. |
format | Online Article Text |
id | pubmed-7219100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-72191002020-05-14 The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population Zhu, Yanli Song, Yuntao Xu, Guohui Fan, Zhihui Ren, Wenhao Chin J Cancer Res Original Article OBJECTIVE: To evaluate the diagnostic utility of The Bethesda System for Reporting Thyroid Cytology (TBSRTC) at Peking University Cancer Hospital, the incidence of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), and the impact of reclassification on cytopathological outcomes. METHODS: We performed a retrospective study of thyroid fine-needle aspiration (FNA) cases between April 2014 and March 2019. The FNA results were classified according to TBSRTC. Post-surgery histological findings were followed up. RESULTS: A total of 2,781 thyroid FNAs were performed. The incidences of the 6 diagnostic categories (DCs I−VI) were 14.8%, 17.1%, 15.8%, 2.3%, 11.6% and 38.5%, respectively. A total of 1,122 patients (40.3%) had corresponding histological results. NIFTP accounted for 0.4% of papillary thyroid carcinoma (PTC) cases, and there was no significant difference in the risk of malignancy (ROM) for each TBSRTC DC between “NIFTP=carcinoma (Ca)” and “NIFTP≠Ca”. When “NIFTP=Ca”, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of TBSRTC were 98.0%, 84.0%, 99.4%, 58.3%, and 97.5%, respectively. When “NIFTP≠Ca”, the sensitivity, specificity, PPV, NPV and accuracy of the TBSRTC were 98.1%, 81.5%, 99.3%, 61.1%, and 97.5%, respectively. CONCLUSIONS: TBSRTC is effective in the preoperative diagnosis of thyroid nodules in Peking University Cancer Hospital. The impact of the reclassification of NIFTP on cytopathological outcomes is limited because of its low incidence, and the revised ROMs are not suitable for Asian patients. AME Publishing Company 2020-04 /pmc/articles/PMC7219100/ /pubmed/32410792 http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.02 Text en Copyright © 2020 Chinese Journal of Cancer Research. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Original Article Zhu, Yanli Song, Yuntao Xu, Guohui Fan, Zhihui Ren, Wenhao The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population |
title | The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population |
title_full | The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population |
title_fullStr | The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population |
title_full_unstemmed | The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population |
title_short | The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): A report of 2,781 cases in a Chinese population |
title_sort | bethesda system for reporting thyroid cytopathology (tbsrtc): a report of 2,781 cases in a chinese population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219100/ https://www.ncbi.nlm.nih.gov/pubmed/32410792 http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.02 |
work_keys_str_mv | AT zhuyanli thebethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT songyuntao thebethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT xuguohui thebethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT fanzhihui thebethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT renwenhao thebethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT zhuyanli bethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT songyuntao bethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT xuguohui bethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT fanzhihui bethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation AT renwenhao bethesdasystemforreportingthyroidcytopathologytbsrtcareportof2781casesinachinesepopulation |