Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure

A screening method for the separation and identification of more than fifty NPS is proposed. The method is based on fast gas-chromatography/time of flight mass spectrometry (FAST-GC/MS-TOF). Thanks to the shorter and narrower capillary column and to the rapid acquisition of the TOF detector a huge n...

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Autores principales: Dei Cas, Michele, Casagni, Eleonora, Arnoldi, Sebastiano, Gambaro, Veniero, Roda, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Interdisciplinary Forensics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219149/
https://www.ncbi.nlm.nih.gov/pubmed/32411957
http://dx.doi.org/10.1016/j.fsisyn.2019.04.003
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author Dei Cas, Michele
Casagni, Eleonora
Arnoldi, Sebastiano
Gambaro, Veniero
Roda, Gabriella
author_facet Dei Cas, Michele
Casagni, Eleonora
Arnoldi, Sebastiano
Gambaro, Veniero
Roda, Gabriella
author_sort Dei Cas, Michele
collection PubMed
description A screening method for the separation and identification of more than fifty NPS is proposed. The method is based on fast gas-chromatography/time of flight mass spectrometry (FAST-GC/MS-TOF). Thanks to the shorter and narrower capillary column and to the rapid acquisition of the TOF detector a huge number of compounds are separated in a very short time of analysis (10 min). Only a few peaks were overlapped. The possibility to apply deconvolution by the software of the GC/MS-TOF instrument allowed the unequivocal identification also for the superimposed peaks. Linearity and LOD was studied and the method was applied to 63 cases of powders seized by the judicial authority at the airport of Milano Malpensa in Northern Italy in the period 2014–2017.
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spelling pubmed-72191492020-05-14 Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure Dei Cas, Michele Casagni, Eleonora Arnoldi, Sebastiano Gambaro, Veniero Roda, Gabriella Forensic Sci Int Interdisciplinary Forensics A screening method for the separation and identification of more than fifty NPS is proposed. The method is based on fast gas-chromatography/time of flight mass spectrometry (FAST-GC/MS-TOF). Thanks to the shorter and narrower capillary column and to the rapid acquisition of the TOF detector a huge number of compounds are separated in a very short time of analysis (10 min). Only a few peaks were overlapped. The possibility to apply deconvolution by the software of the GC/MS-TOF instrument allowed the unequivocal identification also for the superimposed peaks. Linearity and LOD was studied and the method was applied to 63 cases of powders seized by the judicial authority at the airport of Milano Malpensa in Northern Italy in the period 2014–2017. Elsevier 2019-04-14 /pmc/articles/PMC7219149/ /pubmed/32411957 http://dx.doi.org/10.1016/j.fsisyn.2019.04.003 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Interdisciplinary Forensics
Dei Cas, Michele
Casagni, Eleonora
Arnoldi, Sebastiano
Gambaro, Veniero
Roda, Gabriella
Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure
title Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure
title_full Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure
title_fullStr Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure
title_full_unstemmed Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure
title_short Screening of new psychoactive substances (NPS) by gas-chromatography/time of flight mass spectrometry (GC/MS-TOF) and application to 63 cases of judicial seizure
title_sort screening of new psychoactive substances (nps) by gas-chromatography/time of flight mass spectrometry (gc/ms-tof) and application to 63 cases of judicial seizure
topic Interdisciplinary Forensics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219149/
https://www.ncbi.nlm.nih.gov/pubmed/32411957
http://dx.doi.org/10.1016/j.fsisyn.2019.04.003
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