Epigenetic Modification of OXTR is Associated with Openness to Experience

Oxytocin is a neuropeptide known to influence social and cognitive processing across several mammalian species. There currently exists a mixed and controversial pattern of evidence that oxytocin pathway genes confer individual differences in social cognition and personality in humans. Inconsistencie...

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Autores principales: Haas, Brian W., Smith, Alicia K., Nishitani, Shota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Empirical Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219679/
https://www.ncbi.nlm.nih.gov/pubmed/32435727
http://dx.doi.org/10.1017/pen.2018.7
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author Haas, Brian W.
Smith, Alicia K.
Nishitani, Shota
author_facet Haas, Brian W.
Smith, Alicia K.
Nishitani, Shota
author_sort Haas, Brian W.
collection PubMed
description Oxytocin is a neuropeptide known to influence social and cognitive processing across several mammalian species. There currently exists a mixed and controversial pattern of evidence that oxytocin pathway genes confer individual differences in social cognition and personality in humans. Inconsistencies across studies may in part be explained by the presence of intermediary, epigenetic, variables that exist between genotype and phenotype. This study was designed to investigate the association between epigenetic modification of the Oxytocin Receptor Gene (OXTR), via DNA methylation, and Big-5 personality traits. Genetic data were collected via saliva samples and analyzed to quantify DNA methylation within the promoter region of OXTR. The results indicate that Openness to Experience is associated with OXTR DNA methylation, while controlling for the remaining Big-5 personality dimensions (Neuroticism, Extraversion, Agreeableness, and Conscientiousness) and sex and age. This finding provides additional support for models associating oxytocin with individual differences in personality and identity in humans.
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spelling pubmed-72196792020-05-20 Epigenetic Modification of OXTR is Associated with Openness to Experience Haas, Brian W. Smith, Alicia K. Nishitani, Shota Personal Neurosci Empirical Paper Oxytocin is a neuropeptide known to influence social and cognitive processing across several mammalian species. There currently exists a mixed and controversial pattern of evidence that oxytocin pathway genes confer individual differences in social cognition and personality in humans. Inconsistencies across studies may in part be explained by the presence of intermediary, epigenetic, variables that exist between genotype and phenotype. This study was designed to investigate the association between epigenetic modification of the Oxytocin Receptor Gene (OXTR), via DNA methylation, and Big-5 personality traits. Genetic data were collected via saliva samples and analyzed to quantify DNA methylation within the promoter region of OXTR. The results indicate that Openness to Experience is associated with OXTR DNA methylation, while controlling for the remaining Big-5 personality dimensions (Neuroticism, Extraversion, Agreeableness, and Conscientiousness) and sex and age. This finding provides additional support for models associating oxytocin with individual differences in personality and identity in humans. Cambridge University Press 2018-07-18 /pmc/articles/PMC7219679/ /pubmed/32435727 http://dx.doi.org/10.1017/pen.2018.7 Text en © The Authors 2018 http://creativecommons.org/licenses/by-ncnd/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-ncnd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
spellingShingle Empirical Paper
Haas, Brian W.
Smith, Alicia K.
Nishitani, Shota
Epigenetic Modification of OXTR is Associated with Openness to Experience
title Epigenetic Modification of OXTR is Associated with Openness to Experience
title_full Epigenetic Modification of OXTR is Associated with Openness to Experience
title_fullStr Epigenetic Modification of OXTR is Associated with Openness to Experience
title_full_unstemmed Epigenetic Modification of OXTR is Associated with Openness to Experience
title_short Epigenetic Modification of OXTR is Associated with Openness to Experience
title_sort epigenetic modification of oxtr is associated with openness to experience
topic Empirical Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219679/
https://www.ncbi.nlm.nih.gov/pubmed/32435727
http://dx.doi.org/10.1017/pen.2018.7
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