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A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase

The flaviviruses pose serious threats to human health. Being a natural fusion of a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP), NS5 is the most conserved flavivirus protein and an important antiviral target. Previously reported NS5 structures represented by those from the Ja...

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Detalles Bibliográficos
Autores principales:	Wu, Jiqin, Ye, Han-Qing, Zhang, Qiu-Yan, Lu, Guoliang, Zhang, Bo, Gong, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219791/ https://www.ncbi.nlm.nih.gov/pubmed/32357182 http://dx.doi.org/10.1371/journal.ppat.1008484

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