Bowel Perforation in the Emergency Department Related to Bevacizumab Therapy and Recurrent Ovarian Cancer

CASE PRESENTATION: We describe the presentation to the emergency department of a patient with recurrent ovarian cancer treated with bevacizumab with the complication of bowel perforation. DISCUSSION: We review the frequency and outcomes of bevacizumab-related bowel perforation. We also report the pa...

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Detalles Bibliográficos
Autores principales: Ostby, Stuart A., Olushoga, Michael, Leath, Charles A., Burleson, Samuel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: University of California Irvine, Department of Emergency Medicine publishing Western Journal of Emergency Medicine 2020
Materias:
Images in Emergency Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219984/
https://www.ncbi.nlm.nih.gov/pubmed/32426679
http://dx.doi.org/10.5811/cpcem.2020.1.45374
Descripción
Sumario:CASE PRESENTATION: We describe the presentation to the emergency department of a patient with recurrent ovarian cancer treated with bevacizumab with the complication of bowel perforation. DISCUSSION: We review the frequency and outcomes of bevacizumab-related bowel perforation. We also report the patient’s imaging findings, including the radiologic presentation of free intraperitoneal air and portal venous gas, both indicative of bowel perforation and the need for emergent surgical evaluation. Our case also illustrates the potentially catastrophic side effects of bevacizumab and other targeted oncologic therapies of which emergecny physicians may not be aware.

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