A Case Report of Angioedema and Anaphylactic Shock Induced by Ingestion of Polyethylene Glycol

INTRODUCTION: We report one of few documented cases of a severe anaphylactic reaction with angioedema to polyethylene glycol (PEG). CASE REPORT: The patient presented 30 minutes after onset of his symptoms and quickly developed hypoxia and hypotension refractory to intramuscular epinephrine, intravenous fluids, methylprednisolone, and supplemental oxygen via non-rebreather mask. He ultimately required intubation, an epinephrine infusion, and admission to the medical intensive care unit. DISCUSSION: This case depicts a clinical reaction to PEG, a medication rarely implicated in severe anaphylaxis or angioedema. CONCLUSION: The allergenic potential of PEG-containing products should be raised, and providers should have a heightened awareness of these potential side effects.