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Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey
High levels of albuminuria have been demonstrated to associate with hearing loss in non-diabetic people, while the clinical impact of low-grade albuminuria has attracted less attention. This cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic United States (U...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220087/ https://www.ncbi.nlm.nih.gov/pubmed/32176052 http://dx.doi.org/10.1097/MD.0000000000019284 |
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author | Wang, Tang-Chuan Chang, Ta-Yuan Salvi, Richard Juan, Chun-Jung Liu, Yi-Wen Chang, Chia-Hao Chiu, Chien-Jen Lin, Chia-Der Tsai, Ming-Hsui |
author_facet | Wang, Tang-Chuan Chang, Ta-Yuan Salvi, Richard Juan, Chun-Jung Liu, Yi-Wen Chang, Chia-Hao Chiu, Chien-Jen Lin, Chia-Der Tsai, Ming-Hsui |
author_sort | Wang, Tang-Chuan |
collection | PubMed |
description | High levels of albuminuria have been demonstrated to associate with hearing loss in non-diabetic people, while the clinical impact of low-grade albuminuria has attracted less attention. This cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic United States (US) adults is independently associated with low-grade albuminuria or reduced estimated glomeruli filtration rate (eGFR). A total of 2518 participants aged 20 to 69 years were selected from the US National Health and Nutritional Examination Survey database. Participants with diabetes or high-grade albuminuria were excluded. Hearing loss was assessed using low-frequency pure-tone average (LFPTA) thresholds (0.5, 1.0, 2.0 kHz) and high-frequency pure-tone average (HFPTA) thresholds (3.0, 4.0, 6.0, 8.0 kHz). Logistic and linear regression analyses were used to evaluate associations between renal function indicators and hearing loss. The median age of included participants was 37.4 years, and 55% of them were female. Multivariate analysis revealed that participants with urinary albumin-to-creatinine ratio (UACR) in the highest tertile had a significantly higher risk of hearing loss (OR, 1.79; 95% CI, 1.01–3.19) and higher HFPTA thresholds (β: 2.23; SE: 0.77). Participants with eGFR <60 mL/min/1.73 m(2) had higher LFPTA thresholds (β: 4.31; SE: 1.79). After stratification by sex, a significant risk remained only for males in the highest UACR tertile, with 2.18 times the risk of hearing loss (95% CI, 1.06–4.48). Non-diabetic US males with low-grade albuminuria are at increased risk of hearing loss, independent of eGFR. |
format | Online Article Text |
id | pubmed-7220087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-72200872020-06-15 Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey Wang, Tang-Chuan Chang, Ta-Yuan Salvi, Richard Juan, Chun-Jung Liu, Yi-Wen Chang, Chia-Hao Chiu, Chien-Jen Lin, Chia-Der Tsai, Ming-Hsui Medicine (Baltimore) 6000 High levels of albuminuria have been demonstrated to associate with hearing loss in non-diabetic people, while the clinical impact of low-grade albuminuria has attracted less attention. This cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic United States (US) adults is independently associated with low-grade albuminuria or reduced estimated glomeruli filtration rate (eGFR). A total of 2518 participants aged 20 to 69 years were selected from the US National Health and Nutritional Examination Survey database. Participants with diabetes or high-grade albuminuria were excluded. Hearing loss was assessed using low-frequency pure-tone average (LFPTA) thresholds (0.5, 1.0, 2.0 kHz) and high-frequency pure-tone average (HFPTA) thresholds (3.0, 4.0, 6.0, 8.0 kHz). Logistic and linear regression analyses were used to evaluate associations between renal function indicators and hearing loss. The median age of included participants was 37.4 years, and 55% of them were female. Multivariate analysis revealed that participants with urinary albumin-to-creatinine ratio (UACR) in the highest tertile had a significantly higher risk of hearing loss (OR, 1.79; 95% CI, 1.01–3.19) and higher HFPTA thresholds (β: 2.23; SE: 0.77). Participants with eGFR <60 mL/min/1.73 m(2) had higher LFPTA thresholds (β: 4.31; SE: 1.79). After stratification by sex, a significant risk remained only for males in the highest UACR tertile, with 2.18 times the risk of hearing loss (95% CI, 1.06–4.48). Non-diabetic US males with low-grade albuminuria are at increased risk of hearing loss, independent of eGFR. Wolters Kluwer Health 2020-03-13 /pmc/articles/PMC7220087/ /pubmed/32176052 http://dx.doi.org/10.1097/MD.0000000000019284 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 6000 Wang, Tang-Chuan Chang, Ta-Yuan Salvi, Richard Juan, Chun-Jung Liu, Yi-Wen Chang, Chia-Hao Chiu, Chien-Jen Lin, Chia-Der Tsai, Ming-Hsui Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey |
title | Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey |
title_full | Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey |
title_fullStr | Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey |
title_full_unstemmed | Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey |
title_short | Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey |
title_sort | low-grade albuminuria is associated with hearing loss in non-diabetic us males: a cross-sectional analysis of 1999-2004 national health and nutrition examination survey |
topic | 6000 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220087/ https://www.ncbi.nlm.nih.gov/pubmed/32176052 http://dx.doi.org/10.1097/MD.0000000000019284 |
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