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Association of finasteride with prostate cancer: A systematic review and meta-analysis

BACKGROUND: The Prostate Cancer Prevention Trial has shown a protective effect of finasteride on prostate cancer, but it also showed that finasteride can increase the risk of high-grade prostate cancer. Several studies have investigated the relationship between finasteride and prostate cancer, but t...

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Autores principales: Wang, Lei, Lei, Yonghua, Gao, Yanyao, Cui, Dong, Tang, Qisheng, Li, Ruixiao, Wang, Dong, Chen, Yu, Zhang, Bo, Wang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220188/
https://www.ncbi.nlm.nih.gov/pubmed/32282699
http://dx.doi.org/10.1097/MD.0000000000019486
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author Wang, Lei
Lei, Yonghua
Gao, Yanyao
Cui, Dong
Tang, Qisheng
Li, Ruixiao
Wang, Dong
Chen, Yu
Zhang, Bo
Wang, He
author_facet Wang, Lei
Lei, Yonghua
Gao, Yanyao
Cui, Dong
Tang, Qisheng
Li, Ruixiao
Wang, Dong
Chen, Yu
Zhang, Bo
Wang, He
author_sort Wang, Lei
collection PubMed
description BACKGROUND: The Prostate Cancer Prevention Trial has shown a protective effect of finasteride on prostate cancer, but it also showed that finasteride can increase the risk of high-grade prostate cancer. Several studies have investigated the relationship between finasteride and prostate cancer, but these studies have shown inconsistent results. ETHICS: The protocol was approved by the institutional review board of each study center. Written informed consent will be obtained from all patients before registration, in accordance with the Declaration of Helsinki. METHODS: We performed a systematic literature review and meta-analysis to assess the association between finasteride and prostate cancer. Systematic literature searches were conducted using PubMed, EMBASE, Science Direct/Elsevier, MEDLINE, CNKI, and the Cochrane Library up to October 2018 to identify studies that involved the relationship between finasteride and prostate cancer. Meta-analysis was performed using Review Manager and Stata software. Combined ORs were identified with 95% confidence intervals (95% CI) in a random or fixed effects model. RESULTS: Eight studies were identified, including 54,335 cases of patients that used finasteride and 9197 patients who served as placebo controls. Our results illustrate that there is a significant correlation between finasteride use and prostate cancer with combined ORs of 0.70 [0.51, 0.96]. A significant correlation between finasteride use and high-grade prostate cancer was also observed with combined ORs of 2.10 [1.85, 2.38]. CONCLUSIONS: This study confirms that finasteride significantly reduced the risk of prostate cancer; however, the malignant degree of prostate cancer was increased. Studies with larger sample sizes are needed to better clarify the correlation between finasteride use and prostate cancer.
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spelling pubmed-72201882020-06-15 Association of finasteride with prostate cancer: A systematic review and meta-analysis Wang, Lei Lei, Yonghua Gao, Yanyao Cui, Dong Tang, Qisheng Li, Ruixiao Wang, Dong Chen, Yu Zhang, Bo Wang, He Medicine (Baltimore) 5700 BACKGROUND: The Prostate Cancer Prevention Trial has shown a protective effect of finasteride on prostate cancer, but it also showed that finasteride can increase the risk of high-grade prostate cancer. Several studies have investigated the relationship between finasteride and prostate cancer, but these studies have shown inconsistent results. ETHICS: The protocol was approved by the institutional review board of each study center. Written informed consent will be obtained from all patients before registration, in accordance with the Declaration of Helsinki. METHODS: We performed a systematic literature review and meta-analysis to assess the association between finasteride and prostate cancer. Systematic literature searches were conducted using PubMed, EMBASE, Science Direct/Elsevier, MEDLINE, CNKI, and the Cochrane Library up to October 2018 to identify studies that involved the relationship between finasteride and prostate cancer. Meta-analysis was performed using Review Manager and Stata software. Combined ORs were identified with 95% confidence intervals (95% CI) in a random or fixed effects model. RESULTS: Eight studies were identified, including 54,335 cases of patients that used finasteride and 9197 patients who served as placebo controls. Our results illustrate that there is a significant correlation between finasteride use and prostate cancer with combined ORs of 0.70 [0.51, 0.96]. A significant correlation between finasteride use and high-grade prostate cancer was also observed with combined ORs of 2.10 [1.85, 2.38]. CONCLUSIONS: This study confirms that finasteride significantly reduced the risk of prostate cancer; however, the malignant degree of prostate cancer was increased. Studies with larger sample sizes are needed to better clarify the correlation between finasteride use and prostate cancer. Wolters Kluwer Health 2020-04-10 /pmc/articles/PMC7220188/ /pubmed/32282699 http://dx.doi.org/10.1097/MD.0000000000019486 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Wang, Lei
Lei, Yonghua
Gao, Yanyao
Cui, Dong
Tang, Qisheng
Li, Ruixiao
Wang, Dong
Chen, Yu
Zhang, Bo
Wang, He
Association of finasteride with prostate cancer: A systematic review and meta-analysis
title Association of finasteride with prostate cancer: A systematic review and meta-analysis
title_full Association of finasteride with prostate cancer: A systematic review and meta-analysis
title_fullStr Association of finasteride with prostate cancer: A systematic review and meta-analysis
title_full_unstemmed Association of finasteride with prostate cancer: A systematic review and meta-analysis
title_short Association of finasteride with prostate cancer: A systematic review and meta-analysis
title_sort association of finasteride with prostate cancer: a systematic review and meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220188/
https://www.ncbi.nlm.nih.gov/pubmed/32282699
http://dx.doi.org/10.1097/MD.0000000000019486
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