Cargando…
The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis
BACKGROUND: The findings on the association between elevated plasma homocysteine levels and the risk of the trial of org 10172 in acute stroke treatment (TOAST) of ischemic stroke have been inconsistent in Chinese. So far, there is no meta-analysis about the association between Hcy and the TOAST sub...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220264/ https://www.ncbi.nlm.nih.gov/pubmed/32195946 http://dx.doi.org/10.1097/MD.0000000000019467 |
_version_ | 1783533121298235392 |
---|---|
author | Zhang, Tao Jiang, Yuan Zhang, Shuhua Tie, Tingting Cheng, Yan Su, Xiaoming Man, Zhu Hou, Jing Sun, Li Tian, Meiyuan Zhang, Yaogang Li, Jianhua Ma, Yanyan |
author_facet | Zhang, Tao Jiang, Yuan Zhang, Shuhua Tie, Tingting Cheng, Yan Su, Xiaoming Man, Zhu Hou, Jing Sun, Li Tian, Meiyuan Zhang, Yaogang Li, Jianhua Ma, Yanyan |
author_sort | Zhang, Tao |
collection | PubMed |
description | BACKGROUND: The findings on the association between elevated plasma homocysteine levels and the risk of the trial of org 10172 in acute stroke treatment (TOAST) of ischemic stroke have been inconsistent in Chinese. So far, there is no meta-analysis about the association between Hcy and the TOAST subtypes of ischemic stroke in Chinese. This study; therefore, aimed to evaluate whether elevated homocysteine levels are associated with the TOAST subtypes of ischemic stroke using a meta-analysis. MATERIALS AND METHODS: A systematic search of electronic databases were conducted for studies reporting homocysteine levels in ischemic stroke and the TOAST of ischemic stroke to April 18, 2018. The data were extracted after the application of inclusion and exclusion criteria. All the data were analyzed using Stata software version 9.0 (Stata Corp LP, College Station, TX). The standardized mean difference (SMD) and 95% confidence interval (CI) were used to compare continuous variables. RESULTS: Thirteen studies comprising 3114 participants (2243 patients and 871controls) met the eligibility criteria and were included in the meta-analysis. The meta-analysis revealed that the ischemic stroke group had significantly higher levels of homocysteine than controls (SMD = 1.15, 95% CI = 0.85–1.45, P < .05). The subgroup analyses suggested that the groups of patients with large-artery atherosclerosis, small-vessel occlusion, cardioembolism, stroke of other determined etiology and stroke of undetermined etiology had significantly higher levels of homocysteine compared to those in the control group (large-artery atherosclerosis: SMD = 2.12, 95% CI = 1.40–2.84, P < .05; small-vessel occlusion: SMD = 1.10, 95% CI = 0.72–1.48, P < .05; CE: SMD = 1.17, 95% CI = 0.64–1.71, P < .05; stroke of other determined etiology: SMD = 0.88, 95% CI = 0.53–1.24, P < .05; stroke of undetermined etiology: SMD = 1.50, 95% CI = 0.66–2.33, P < .05, respectively). CONCLUSION: This meta-analysis found that ischemic stroke patients and the TOAST of ischemic stroke patients in Chinese had significantly higher homocysteine levels than the controls, suggesting that serum homocysteine levels may be a risk factor for ischemic stroke and the TOAST subtypes of ischemic stroke in Chinese. |
format | Online Article Text |
id | pubmed-7220264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-72202642020-06-15 The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis Zhang, Tao Jiang, Yuan Zhang, Shuhua Tie, Tingting Cheng, Yan Su, Xiaoming Man, Zhu Hou, Jing Sun, Li Tian, Meiyuan Zhang, Yaogang Li, Jianhua Ma, Yanyan Medicine (Baltimore) 5300 BACKGROUND: The findings on the association between elevated plasma homocysteine levels and the risk of the trial of org 10172 in acute stroke treatment (TOAST) of ischemic stroke have been inconsistent in Chinese. So far, there is no meta-analysis about the association between Hcy and the TOAST subtypes of ischemic stroke in Chinese. This study; therefore, aimed to evaluate whether elevated homocysteine levels are associated with the TOAST subtypes of ischemic stroke using a meta-analysis. MATERIALS AND METHODS: A systematic search of electronic databases were conducted for studies reporting homocysteine levels in ischemic stroke and the TOAST of ischemic stroke to April 18, 2018. The data were extracted after the application of inclusion and exclusion criteria. All the data were analyzed using Stata software version 9.0 (Stata Corp LP, College Station, TX). The standardized mean difference (SMD) and 95% confidence interval (CI) were used to compare continuous variables. RESULTS: Thirteen studies comprising 3114 participants (2243 patients and 871controls) met the eligibility criteria and were included in the meta-analysis. The meta-analysis revealed that the ischemic stroke group had significantly higher levels of homocysteine than controls (SMD = 1.15, 95% CI = 0.85–1.45, P < .05). The subgroup analyses suggested that the groups of patients with large-artery atherosclerosis, small-vessel occlusion, cardioembolism, stroke of other determined etiology and stroke of undetermined etiology had significantly higher levels of homocysteine compared to those in the control group (large-artery atherosclerosis: SMD = 2.12, 95% CI = 1.40–2.84, P < .05; small-vessel occlusion: SMD = 1.10, 95% CI = 0.72–1.48, P < .05; CE: SMD = 1.17, 95% CI = 0.64–1.71, P < .05; stroke of other determined etiology: SMD = 0.88, 95% CI = 0.53–1.24, P < .05; stroke of undetermined etiology: SMD = 1.50, 95% CI = 0.66–2.33, P < .05, respectively). CONCLUSION: This meta-analysis found that ischemic stroke patients and the TOAST of ischemic stroke patients in Chinese had significantly higher homocysteine levels than the controls, suggesting that serum homocysteine levels may be a risk factor for ischemic stroke and the TOAST subtypes of ischemic stroke in Chinese. Wolters Kluwer Health 2020-03-20 /pmc/articles/PMC7220264/ /pubmed/32195946 http://dx.doi.org/10.1097/MD.0000000000019467 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5300 Zhang, Tao Jiang, Yuan Zhang, Shuhua Tie, Tingting Cheng, Yan Su, Xiaoming Man, Zhu Hou, Jing Sun, Li Tian, Meiyuan Zhang, Yaogang Li, Jianhua Ma, Yanyan The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis |
title | The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis |
title_full | The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis |
title_fullStr | The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis |
title_full_unstemmed | The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis |
title_short | The association between homocysteine and ischemic stroke subtypes in Chinese: A meta-analysis |
title_sort | association between homocysteine and ischemic stroke subtypes in chinese: a meta-analysis |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220264/ https://www.ncbi.nlm.nih.gov/pubmed/32195946 http://dx.doi.org/10.1097/MD.0000000000019467 |
work_keys_str_mv | AT zhangtao theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT jiangyuan theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT zhangshuhua theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT tietingting theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT chengyan theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT suxiaoming theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT manzhu theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT houjing theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT sunli theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT tianmeiyuan theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT zhangyaogang theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT lijianhua theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT mayanyan theassociationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT zhangtao associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT jiangyuan associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT zhangshuhua associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT tietingting associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT chengyan associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT suxiaoming associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT manzhu associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT houjing associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT sunli associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT tianmeiyuan associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT zhangyaogang associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT lijianhua associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis AT mayanyan associationbetweenhomocysteineandischemicstrokesubtypesinchineseametaanalysis |