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Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol

BACKGROUND: Type 2 diabetes mellitus is a common health problem in the world. The overall goal of diabetes management is to control blood glucose and lipids, so as to reduce the incidence of complications. Pueraria, scutellaria, and coptis decoction (PSCD) is 1 of the representative Traditional Chin...

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Autores principales: Yang, Maoyi, Hu, Zhipeng, Yue, Rensong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220274/
https://www.ncbi.nlm.nih.gov/pubmed/32311982
http://dx.doi.org/10.1097/MD.0000000000019770
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author Yang, Maoyi
Hu, Zhipeng
Yue, Rensong
author_facet Yang, Maoyi
Hu, Zhipeng
Yue, Rensong
author_sort Yang, Maoyi
collection PubMed
description BACKGROUND: Type 2 diabetes mellitus is a common health problem in the world. The overall goal of diabetes management is to control blood glucose and lipids, so as to reduce the incidence of complications. Pueraria, scutellaria, and coptis decoction (PSCD) is 1 of the representative Traditional Chinese medicine formula in the treatment of diabetes, which is widely used in clinical practice in China. At present, there are many clinical reports about this formula, but these reports have their own defects. Therefore, there is an urgent need for a systematic review and meta-analysis to synthesize the current clinical evidence. METHODS AND ANALYSIS: A comprehensive literature search will be conducted and randomized controlled trials will be selected according to inclusion and exclusion criteria. Fasting blood glucose and 2 hours postprandial blood glucose will be selected as the main outcomes. The secondary outcomes are glycated hemoglobin, fasting insulin, total cholesterol, glycerol, low-density cholesterol, high-density cholesterol and adverse effects. Chi-square and I(2) test will be used to test the heterogeneity of the study. Subgroup analysis will be conducted to explore the source of heterogeneity and sensitivity will be conducted to test the stability of the results. Funnel plot will be used to evaluate publication bias. Finally, the Grading of Recommendations Assessment, Development and Evaluate system will be used to summarize the quality of evidence. RESULTS: The results will be published in peer-reviewed journals. CONCLUSION: This research will evaluate the efficacy of Pueraria, scutellaria, and coptis decoction in the treatment of type 2 diabetes mellitus patients. It will provide strong evidence-based support for clinical practice. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/WVDE5
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spelling pubmed-72202742020-06-15 Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol Yang, Maoyi Hu, Zhipeng Yue, Rensong Medicine (Baltimore) 3800 BACKGROUND: Type 2 diabetes mellitus is a common health problem in the world. The overall goal of diabetes management is to control blood glucose and lipids, so as to reduce the incidence of complications. Pueraria, scutellaria, and coptis decoction (PSCD) is 1 of the representative Traditional Chinese medicine formula in the treatment of diabetes, which is widely used in clinical practice in China. At present, there are many clinical reports about this formula, but these reports have their own defects. Therefore, there is an urgent need for a systematic review and meta-analysis to synthesize the current clinical evidence. METHODS AND ANALYSIS: A comprehensive literature search will be conducted and randomized controlled trials will be selected according to inclusion and exclusion criteria. Fasting blood glucose and 2 hours postprandial blood glucose will be selected as the main outcomes. The secondary outcomes are glycated hemoglobin, fasting insulin, total cholesterol, glycerol, low-density cholesterol, high-density cholesterol and adverse effects. Chi-square and I(2) test will be used to test the heterogeneity of the study. Subgroup analysis will be conducted to explore the source of heterogeneity and sensitivity will be conducted to test the stability of the results. Funnel plot will be used to evaluate publication bias. Finally, the Grading of Recommendations Assessment, Development and Evaluate system will be used to summarize the quality of evidence. RESULTS: The results will be published in peer-reviewed journals. CONCLUSION: This research will evaluate the efficacy of Pueraria, scutellaria, and coptis decoction in the treatment of type 2 diabetes mellitus patients. It will provide strong evidence-based support for clinical practice. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/WVDE5 Wolters Kluwer Health 2020-04-17 /pmc/articles/PMC7220274/ /pubmed/32311982 http://dx.doi.org/10.1097/MD.0000000000019770 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 3800
Yang, Maoyi
Hu, Zhipeng
Yue, Rensong
Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol
title Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol
title_full Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol
title_fullStr Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol
title_full_unstemmed Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol
title_short Effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: A systematic review and meta-analysis protocol
title_sort effect of pueraria, scutellaria, and coptis decoction for type 2 diabetes: a systematic review and meta-analysis protocol
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220274/
https://www.ncbi.nlm.nih.gov/pubmed/32311982
http://dx.doi.org/10.1097/MD.0000000000019770
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