Cargando…
Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
Leukocytes telomere length has been associated with hypertension, but, whether longitudinal telomeres change could serve as a useful predictive tool in hypertension remains uncertain. This study aimed to examine the longitudinal trajectory of leukocytes telomere length in a population-based prospect...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220288/ https://www.ncbi.nlm.nih.gov/pubmed/32489697 http://dx.doi.org/10.14336/AD.2019.0721 |
_version_ | 1783533126806405120 |
---|---|
author | Zhang, Shuyuan Li, Rongxia Yang, Yunyun Chen, Yu Yang, Shujun Li, Jian Wu, Cunjin Kong, Tao Liu, Tianlong Cai, Jun Fu, Li Zhao, Yanan Hui, Rutai Zhang, Weili |
author_facet | Zhang, Shuyuan Li, Rongxia Yang, Yunyun Chen, Yu Yang, Shujun Li, Jian Wu, Cunjin Kong, Tao Liu, Tianlong Cai, Jun Fu, Li Zhao, Yanan Hui, Rutai Zhang, Weili |
author_sort | Zhang, Shuyuan |
collection | PubMed |
description | Leukocytes telomere length has been associated with hypertension, but, whether longitudinal telomeres change could serve as a useful predictive tool in hypertension remains uncertain. This study aimed to examine the longitudinal trajectory of leukocytes telomere length in a population-based prospective study of 1,108 individuals with hypertension. Leukocytes telomere length were measured at baseline and again after a median 2.2 (range 1.5-2.4) years of follow-up. Age as an independent predictor was inversely associated with baseline telomeres and follow-up telomeres. Annual telomere attrition rate was calculated as (follow-up telomeres-baseline telomeres)/follow-up years, and participants were categorized into the shorten and the lengthen groups. Results showed that telomere lengthening was significantly correlated with decreased systolic blood pressure (SBP) (β=-3.28; P=0.02) and pulse pressure (PP) (β=-2.53; P=0.02), and the differences were respectively -3.3 mmHg (95%CI, -6.2 to -0.3; P=0.03) in ∆SBP and -2.4 mmHg (95%CI, -4.9 to -0.1; P=0.04) in ∆PP between two groups after adjustment for vascular risk factors and baseline blood pressures. When stratified by age and gender, the correlations were observed in women and patients ≤60 years. Furthermore, among patients using calcium channel blocker (CCB) and angiotensin receptor blocker (ARB), those with telomeres lengthening showed a significantly lower level of ∆SBP and ∆PP. There was no correlation between telomere attrition and incidence of cardiovascular events. Our data indicated that increased telomere length of leukocytes was associated with decreased SBP and PP, particularly for patients who received CCB and ARB, supporting that telomere attrition may provide new sight in clinical intervention for hypertension. |
format | Online Article Text |
id | pubmed-7220288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-72202882020-06-01 Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering Zhang, Shuyuan Li, Rongxia Yang, Yunyun Chen, Yu Yang, Shujun Li, Jian Wu, Cunjin Kong, Tao Liu, Tianlong Cai, Jun Fu, Li Zhao, Yanan Hui, Rutai Zhang, Weili Aging Dis Orginal Article Leukocytes telomere length has been associated with hypertension, but, whether longitudinal telomeres change could serve as a useful predictive tool in hypertension remains uncertain. This study aimed to examine the longitudinal trajectory of leukocytes telomere length in a population-based prospective study of 1,108 individuals with hypertension. Leukocytes telomere length were measured at baseline and again after a median 2.2 (range 1.5-2.4) years of follow-up. Age as an independent predictor was inversely associated with baseline telomeres and follow-up telomeres. Annual telomere attrition rate was calculated as (follow-up telomeres-baseline telomeres)/follow-up years, and participants were categorized into the shorten and the lengthen groups. Results showed that telomere lengthening was significantly correlated with decreased systolic blood pressure (SBP) (β=-3.28; P=0.02) and pulse pressure (PP) (β=-2.53; P=0.02), and the differences were respectively -3.3 mmHg (95%CI, -6.2 to -0.3; P=0.03) in ∆SBP and -2.4 mmHg (95%CI, -4.9 to -0.1; P=0.04) in ∆PP between two groups after adjustment for vascular risk factors and baseline blood pressures. When stratified by age and gender, the correlations were observed in women and patients ≤60 years. Furthermore, among patients using calcium channel blocker (CCB) and angiotensin receptor blocker (ARB), those with telomeres lengthening showed a significantly lower level of ∆SBP and ∆PP. There was no correlation between telomere attrition and incidence of cardiovascular events. Our data indicated that increased telomere length of leukocytes was associated with decreased SBP and PP, particularly for patients who received CCB and ARB, supporting that telomere attrition may provide new sight in clinical intervention for hypertension. JKL International LLC 2019-07-21 /pmc/articles/PMC7220288/ /pubmed/32489697 http://dx.doi.org/10.14336/AD.2019.0721 Text en Copyright: © 2020 Zhang et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Orginal Article Zhang, Shuyuan Li, Rongxia Yang, Yunyun Chen, Yu Yang, Shujun Li, Jian Wu, Cunjin Kong, Tao Liu, Tianlong Cai, Jun Fu, Li Zhao, Yanan Hui, Rutai Zhang, Weili Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering |
title | Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering |
title_full | Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering |
title_fullStr | Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering |
title_full_unstemmed | Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering |
title_short | Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering |
title_sort | longitudinal association of telomere attrition with the effects of antihypertensive treatment and blood pressure lowering |
topic | Orginal Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220288/ https://www.ncbi.nlm.nih.gov/pubmed/32489697 http://dx.doi.org/10.14336/AD.2019.0721 |
work_keys_str_mv | AT zhangshuyuan longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT lirongxia longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT yangyunyun longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT chenyu longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT yangshujun longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT lijian longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT wucunjin longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT kongtao longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT liutianlong longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT caijun longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT fuli longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT zhaoyanan longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT huirutai longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering AT zhangweili longitudinalassociationoftelomereattritionwiththeeffectsofantihypertensivetreatmentandbloodpressurelowering |