COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?

The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable...

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Detalles Bibliográficos
Autores principales: Chakrabarti, Sankha Shubhra, Kaur, Upinder, Banerjee, Anindita, Ganguly, Upasana, Banerjee, Tuhina, Saha, Sarama, Parashar, Gaurav, Prasad, Suvarna, Chakrabarti, Suddhachitta, Mittal, Amit, Agrawal, Bimal Kumar, Rawal, Ravindra Kumar, Zhao, Robert Chunhua, Gambhir, Indrajeet Singh, Khanna, Rahul, Shetty, Ashok K, Jin, Kunlin, Chakrabarti, Sasanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220291/
https://www.ncbi.nlm.nih.gov/pubmed/32489695
http://dx.doi.org/10.14336/AD.2020.0402
Descripción
Sumario:The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.

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