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CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis
BACKGROUND: Number of studies have been performed to evaluate the relationship between the cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) gene variant rs5742909 polymorphism and cervical cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conduct...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220313/ https://www.ncbi.nlm.nih.gov/pubmed/32176070 http://dx.doi.org/10.1097/MD.0000000000019433 |
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author | Hu, ShiWan Pu, Dan Xia, XueYi Guo, BeiXi Zhang, ChuanLi |
author_facet | Hu, ShiWan Pu, Dan Xia, XueYi Guo, BeiXi Zhang, ChuanLi |
author_sort | Hu, ShiWan |
collection | PubMed |
description | BACKGROUND: Number of studies have been performed to evaluate the relationship between the cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) gene variant rs5742909 polymorphism and cervical cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively evaluate the overall association. METHODS: PubMed, Web of Science, Embase, China Biology Medical Literature database, China National Knowledge Infrastructure, WanFang, and Weipu databases were searched before July 31, 2018. The strength of associations was assessed using odds ratios (ORs) and 95% confidence intervals (CIs). All of the statistical analyses were conducted using Review Manager 5.3 and Stata 14.0. RESULTS: Eleven studies involved 3899 cases and 4608 controls. Overall, significant association was observed between the CTLA-4 gene variant rs5742909 polymorphism and cervical cancer (T vs C: OR = 1.40, 95% CI = 1.12–1.76; TT vs CC: OR = 2.22, 95% CI = 1.13–4.37; TT vs CT+CC: OR = 1.96, 95% CI = 1.03–3.74; TT+CT vs CC: OR = 1.47, 95% CI = 1.14–1.90). In subgroup analysis by ethnic group, a statistically significant association was observed in Asians (T vs C: OR = 1.56, 95% CI = 1.22–1.99), but not in Caucasians (T vs C: OR = 1.19, 95% CI = 0.87–1.62). The sensitivity analysis confirmed the reliability and stability of the meta-analysis. CONCLUSION: our meta-analysis supports that the CTLA-4 gene variant rs5742909 polymorphism might contribute to individual susceptibility to cervical cancer in Asians. |
format | Online Article Text |
id | pubmed-7220313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-72203132020-06-15 CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis Hu, ShiWan Pu, Dan Xia, XueYi Guo, BeiXi Zhang, ChuanLi Medicine (Baltimore) 5600 BACKGROUND: Number of studies have been performed to evaluate the relationship between the cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) gene variant rs5742909 polymorphism and cervical cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively evaluate the overall association. METHODS: PubMed, Web of Science, Embase, China Biology Medical Literature database, China National Knowledge Infrastructure, WanFang, and Weipu databases were searched before July 31, 2018. The strength of associations was assessed using odds ratios (ORs) and 95% confidence intervals (CIs). All of the statistical analyses were conducted using Review Manager 5.3 and Stata 14.0. RESULTS: Eleven studies involved 3899 cases and 4608 controls. Overall, significant association was observed between the CTLA-4 gene variant rs5742909 polymorphism and cervical cancer (T vs C: OR = 1.40, 95% CI = 1.12–1.76; TT vs CC: OR = 2.22, 95% CI = 1.13–4.37; TT vs CT+CC: OR = 1.96, 95% CI = 1.03–3.74; TT+CT vs CC: OR = 1.47, 95% CI = 1.14–1.90). In subgroup analysis by ethnic group, a statistically significant association was observed in Asians (T vs C: OR = 1.56, 95% CI = 1.22–1.99), but not in Caucasians (T vs C: OR = 1.19, 95% CI = 0.87–1.62). The sensitivity analysis confirmed the reliability and stability of the meta-analysis. CONCLUSION: our meta-analysis supports that the CTLA-4 gene variant rs5742909 polymorphism might contribute to individual susceptibility to cervical cancer in Asians. Wolters Kluwer Health 2020-03-13 /pmc/articles/PMC7220313/ /pubmed/32176070 http://dx.doi.org/10.1097/MD.0000000000019433 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5600 Hu, ShiWan Pu, Dan Xia, XueYi Guo, BeiXi Zhang, ChuanLi CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis |
title | CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis |
title_full | CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis |
title_fullStr | CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis |
title_full_unstemmed | CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis |
title_short | CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis |
title_sort | ctla-4 rs5742909 polymorphism and cervical cancer risk: a meta-analysis |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220313/ https://www.ncbi.nlm.nih.gov/pubmed/32176070 http://dx.doi.org/10.1097/MD.0000000000019433 |
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