Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates

Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)–rich protein aggregates [termed “Lewy bodies” (LBs)], is a well-established characteristic of Parkinson’s disease (PD). Much evidence, accumulated from multiple experimental models, has suggested that α-syn plays a r...

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Detalles Bibliográficos
Autores principales: Bourdenx, M., Nioche, A., Dovero, S., Arotcarena, M.-L., Camus, S., Porras, G., Thiolat, M.-L., Rougier, N. P., Prigent, A., Aubert, P., Bohic, S., Sandt, C., Laferrière, F., Doudnikoff, E., Kruse, N., Mollenhauer, B., Novello, S., Morari, M., Leste-Lasserre, T., Trigo-Damas, I., Goillandeau, M., Perier, C., Estrada, C., Garcia-Carrillo, N., Recasens, A., Vaikath, N. N., El-Agnaf, O. M. A., Herrero, M. T., Derkinderen, P., Vila, M., Obeso, J. A., Dehay, B., Bezard, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220339/
https://www.ncbi.nlm.nih.gov/pubmed/32426502
http://dx.doi.org/10.1126/sciadv.aaz9165

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