Competition between PAF1 and MLL1/COMPASS confers the opposing function of LEDGF/p75 in HIV latency and proviral reactivation

Transcriptional status determines the HIV replicative state in infected patients. However, the transcriptional mechanisms for proviral replication control remain unclear. In this study, we show that, apart from its function in HIV integration, LEDGF/p75 differentially regulates HIV transcription in...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Ru, Bao, Jiaqian, Yan, Han, Xie, Liya, Qin, Wanchang, Ning, Hanhan, Huang, Shuqi, Cheng, Jun, Zhi, Renyong, Li, Zexing, Tucker, Bronwyn, Chen, Yupeng, Zhang, Kai, Wu, Xudong, Liu, Zhe, Gao, Xin, Hu, Deqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220354/
https://www.ncbi.nlm.nih.gov/pubmed/32426500
http://dx.doi.org/10.1126/sciadv.aaz8411

Ejemplares similares

Ejemplares similares