Cargando…
Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
Calcium (Ca(2+))-evoked release of neurotransmitters from synaptic vesicles requires mechanisms both to prevent un-initiated fusion of vesicles (clamping) and to trigger fusion following Ca(2+)-influx. The principal components involved in these processes are the vesicular fusion machinery (SNARE pro...
Autores principales: | Ramakrishnan, Sathish, Bera, Manindra, Coleman, Jeff, Rothman, James E, Krishnakumar, Shyam S |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220375/ https://www.ncbi.nlm.nih.gov/pubmed/32401194 http://dx.doi.org/10.7554/eLife.54506 |
Ejemplares similares
-
Molecular determinants of complexin clamping and activation function
por: Bera, Manindra, et al.
Publicado: (2022) -
Synaptotagmin oligomers are necessary and can be sufficient to form a Ca(2+)‐sensitive fusion clamp
por: Ramakrishnan, Sathish, et al.
Publicado: (2019) -
All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer
por: Rizo, Josep, et al.
Publicado: (2022) -
Re-examining how complexin inhibits neurotransmitter release
por: Trimbuch, Thorsten, et al.
Publicado: (2014) -
Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes
por: Prinslow, Eric A, et al.
Publicado: (2017)