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Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is the major cause of cancer mortality worldwide. Though multidisciplinary therapies have been widely used for NSCLC, its overall prognosis remains very poor, presumably owing to lack of effective prognostic biomarkers. SMAD, a well-known transcription factor, play...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220383/ https://www.ncbi.nlm.nih.gov/pubmed/32150102 http://dx.doi.org/10.1097/MD.0000000000019451 |
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author | Zeng, Zhenguo Yang, Yuting Qing, Cheng Hu, Zhiguo Huang, Yiming Zhou, Chaoqi Li, Dan Jiang, Yanxia |
author_facet | Zeng, Zhenguo Yang, Yuting Qing, Cheng Hu, Zhiguo Huang, Yiming Zhou, Chaoqi Li, Dan Jiang, Yanxia |
author_sort | Zeng, Zhenguo |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is the major cause of cancer mortality worldwide. Though multidisciplinary therapies have been widely used for NSCLC, its overall prognosis remains very poor, presumably owing to lack of effective prognostic biomarkers. SMAD, a well-known transcription factor, plays an essential role in carcinogenesis. Aberrant expression of SMAD have been found in various cancers, and may be regarded as prognostic indicator for some malignancies. However, the expression and prognostic role of SMAD family member, especially at the mRNA level, remain elusive in NSCLC. In the present study, we report the distinct expression and prognostic value of individual SMAD in patients with NSCLC by analyzing several online databases including ONCOMINE, Gene Expression Profiling Interactive Analysis, Human Protein Atlas database, Kaplan–Meier plotter, cBioPortal, and Database for Annotation, Visualization and Integrated Discovery. The mRNA levels of SMAD6/7/9 in NSCLC were significantly down-regulated in NSCLC, and aberrant SMAD2/3/4/5/6/7/9 mRNA levels were all correlated with the prognosis of NSCLC. Collectively, SMAD2/3/4/5/6/7/9 may server as prognostic biomarkers and potential targets for NSCLC, and thus facilitate the customized treatment strategies for NSCLC patients. |
format | Online Article Text |
id | pubmed-7220383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-72203832020-06-15 Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer Zeng, Zhenguo Yang, Yuting Qing, Cheng Hu, Zhiguo Huang, Yiming Zhou, Chaoqi Li, Dan Jiang, Yanxia Medicine (Baltimore) 5700 Non-small cell lung cancer (NSCLC) is the major cause of cancer mortality worldwide. Though multidisciplinary therapies have been widely used for NSCLC, its overall prognosis remains very poor, presumably owing to lack of effective prognostic biomarkers. SMAD, a well-known transcription factor, plays an essential role in carcinogenesis. Aberrant expression of SMAD have been found in various cancers, and may be regarded as prognostic indicator for some malignancies. However, the expression and prognostic role of SMAD family member, especially at the mRNA level, remain elusive in NSCLC. In the present study, we report the distinct expression and prognostic value of individual SMAD in patients with NSCLC by analyzing several online databases including ONCOMINE, Gene Expression Profiling Interactive Analysis, Human Protein Atlas database, Kaplan–Meier plotter, cBioPortal, and Database for Annotation, Visualization and Integrated Discovery. The mRNA levels of SMAD6/7/9 in NSCLC were significantly down-regulated in NSCLC, and aberrant SMAD2/3/4/5/6/7/9 mRNA levels were all correlated with the prognosis of NSCLC. Collectively, SMAD2/3/4/5/6/7/9 may server as prognostic biomarkers and potential targets for NSCLC, and thus facilitate the customized treatment strategies for NSCLC patients. Wolters Kluwer Health 2020-03-06 /pmc/articles/PMC7220383/ /pubmed/32150102 http://dx.doi.org/10.1097/MD.0000000000019451 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5700 Zeng, Zhenguo Yang, Yuting Qing, Cheng Hu, Zhiguo Huang, Yiming Zhou, Chaoqi Li, Dan Jiang, Yanxia Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer |
title | Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer |
title_full | Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer |
title_fullStr | Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer |
title_full_unstemmed | Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer |
title_short | Distinct expression and prognostic value of members of SMAD family in non-small cell lung cancer |
title_sort | distinct expression and prognostic value of members of smad family in non-small cell lung cancer |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220383/ https://www.ncbi.nlm.nih.gov/pubmed/32150102 http://dx.doi.org/10.1097/MD.0000000000019451 |
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