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Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI

Altered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed s...

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Autores principales: Huang, Jianpan, van Zijl, Peter C. M., Han, Xiongqi, Dong, Celia M., Cheng, Gerald W. Y., Tse, Kai-Hei, Knutsson, Linda, Chen, Lin, Lai, Joseph H. C., Wu, Ed X., Xu, Jiadi, Chan, Kannie W. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220384/
https://www.ncbi.nlm.nih.gov/pubmed/32426510
http://dx.doi.org/10.1126/sciadv.aba3884
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author Huang, Jianpan
van Zijl, Peter C. M.
Han, Xiongqi
Dong, Celia M.
Cheng, Gerald W. Y.
Tse, Kai-Hei
Knutsson, Linda
Chen, Lin
Lai, Joseph H. C.
Wu, Ed X.
Xu, Jiadi
Chan, Kannie W. Y.
author_facet Huang, Jianpan
van Zijl, Peter C. M.
Han, Xiongqi
Dong, Celia M.
Cheng, Gerald W. Y.
Tse, Kai-Hei
Knutsson, Linda
Chen, Lin
Lai, Joseph H. C.
Wu, Ed X.
Xu, Jiadi
Chan, Kannie W. Y.
author_sort Huang, Jianpan
collection PubMed
description Altered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.
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spelling pubmed-72203842020-05-18 Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI Huang, Jianpan van Zijl, Peter C. M. Han, Xiongqi Dong, Celia M. Cheng, Gerald W. Y. Tse, Kai-Hei Knutsson, Linda Chen, Lin Lai, Joseph H. C. Wu, Ed X. Xu, Jiadi Chan, Kannie W. Y. Sci Adv Research Articles Altered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI. American Association for the Advancement of Science 2020-05-13 /pmc/articles/PMC7220384/ /pubmed/32426510 http://dx.doi.org/10.1126/sciadv.aba3884 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Huang, Jianpan
van Zijl, Peter C. M.
Han, Xiongqi
Dong, Celia M.
Cheng, Gerald W. Y.
Tse, Kai-Hei
Knutsson, Linda
Chen, Lin
Lai, Joseph H. C.
Wu, Ed X.
Xu, Jiadi
Chan, Kannie W. Y.
Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
title Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
title_full Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
title_fullStr Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
title_full_unstemmed Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
title_short Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
title_sort altered d-glucose in brain parenchyma and cerebrospinal fluid of early alzheimer’s disease detected by dynamic glucose-enhanced mri
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220384/
https://www.ncbi.nlm.nih.gov/pubmed/32426510
http://dx.doi.org/10.1126/sciadv.aba3884
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