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Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients
The endoscopic endonasal transsphenoidal approach (EETA) is the primary treatment for growth hormone (GH) adenoma. This study aimed to investigate the outcomes of EETA in 33 patients with GH-secreting pituitary adenoma (PA). Thirty-three patients who underwent EETA in Eighth People's Hospital o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220440/ https://www.ncbi.nlm.nih.gov/pubmed/32384430 http://dx.doi.org/10.1097/MD.0000000000019855 |
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author | Zheng, Yong Chen, Dong-Ming Wang, Yan Mai, Rong-Kang Zhu, Zi-Feng |
author_facet | Zheng, Yong Chen, Dong-Ming Wang, Yan Mai, Rong-Kang Zhu, Zi-Feng |
author_sort | Zheng, Yong |
collection | PubMed |
description | The endoscopic endonasal transsphenoidal approach (EETA) is the primary treatment for growth hormone (GH) adenoma. This study aimed to investigate the outcomes of EETA in 33 patients with GH-secreting pituitary adenoma (PA). Thirty-three patients who underwent EETA in Eighth People's Hospital of Shenzhen between January 2013 and December 2017 were included in the comprehensive analysis. Factors affecting the extent of resection and postoperative remission rates were also reviewed. The total cut rate was 63.6% (21), and the total remission rate was 66.7% (22) in all patients after surgery. The cure rate was 60.6% (20) for 33 patients. The total removal rate and remission rate were significantly different (P = .01, P = .007) for microadenomas, macroadenomas, and giant adenomas. In addition, the total removal rate and remission rate were significantly different (P = .004, P = .007) for patients with noninvasive and invasive GH-secreting PAs. Furthermore, there were significant differences (P = .003, P = .005) in the total removal rate and remission rate of patients with different preoperative GH levels. All patients with hypertension and diabetes mellitus were normalized. Three patients exhibited recurrence after surgery. Several patients suffered from postoperative complications, including transient diabetes insipidus in 3 (9.1%) patients and postoperative transient cerebrospinal fluid leakage in 2 (6.1%) patients. EETA is an effective therapeutic approach for treating patients with GH-secreting PA with high remission and low complication rates. Therefore, EETA should be considered a primary treatment for patients with GH-secreting PA. |
format | Online Article Text |
id | pubmed-7220440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-72204402020-06-15 Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients Zheng, Yong Chen, Dong-Ming Wang, Yan Mai, Rong-Kang Zhu, Zi-Feng Medicine (Baltimore) 7100 The endoscopic endonasal transsphenoidal approach (EETA) is the primary treatment for growth hormone (GH) adenoma. This study aimed to investigate the outcomes of EETA in 33 patients with GH-secreting pituitary adenoma (PA). Thirty-three patients who underwent EETA in Eighth People's Hospital of Shenzhen between January 2013 and December 2017 were included in the comprehensive analysis. Factors affecting the extent of resection and postoperative remission rates were also reviewed. The total cut rate was 63.6% (21), and the total remission rate was 66.7% (22) in all patients after surgery. The cure rate was 60.6% (20) for 33 patients. The total removal rate and remission rate were significantly different (P = .01, P = .007) for microadenomas, macroadenomas, and giant adenomas. In addition, the total removal rate and remission rate were significantly different (P = .004, P = .007) for patients with noninvasive and invasive GH-secreting PAs. Furthermore, there were significant differences (P = .003, P = .005) in the total removal rate and remission rate of patients with different preoperative GH levels. All patients with hypertension and diabetes mellitus were normalized. Three patients exhibited recurrence after surgery. Several patients suffered from postoperative complications, including transient diabetes insipidus in 3 (9.1%) patients and postoperative transient cerebrospinal fluid leakage in 2 (6.1%) patients. EETA is an effective therapeutic approach for treating patients with GH-secreting PA with high remission and low complication rates. Therefore, EETA should be considered a primary treatment for patients with GH-secreting PA. Wolters Kluwer Health 2020-05-08 /pmc/articles/PMC7220440/ /pubmed/32384430 http://dx.doi.org/10.1097/MD.0000000000019855 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 7100 Zheng, Yong Chen, Dong-Ming Wang, Yan Mai, Rong-Kang Zhu, Zi-Feng Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients |
title | Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients |
title_full | Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients |
title_fullStr | Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients |
title_full_unstemmed | Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients |
title_short | Surgical management of growth hormone-secreting pituitary adenomas: A retrospective analysis of 33 patients |
title_sort | surgical management of growth hormone-secreting pituitary adenomas: a retrospective analysis of 33 patients |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220440/ https://www.ncbi.nlm.nih.gov/pubmed/32384430 http://dx.doi.org/10.1097/MD.0000000000019855 |
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