Cargando…

Co-occurrence of PML-RARA gene fusion, chromosome 8 trisomy, and FLT3 ITD mutation in a young female patient with de novo acute myeloid leukemia and early death: A CARE case report

RATIONALE: Co-occurrence of cytogenetic and molecular abnormalities is frequently seen in patients with acute myeloid leukemia (AML). The clinical outcome and genetic abnormalities of AML may vary; therefore, genetic investigation must be complex, using several techniques, to have an appropriate cha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tripon, Florin, Crauciuc, George Andrei, Bogliş, Alina, Moldovan, Valeriu, Sándor-Kéri, Johanna, Benedek, István Jr, Trifa, Adrian Pavel, Bănescu, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2020
Materias:	4800
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220460/ https://www.ncbi.nlm.nih.gov/pubmed/32243411 http://dx.doi.org/10.1097/MD.0000000000019730

Ejemplares similares

TERT rs2853669 as a predictor for overall survival in patients with acute myeloid leukaemia
por: Tripon, Florin, et al.
Publicado: (2021)

Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia
por: Bănescu, Claudia, et al.
Publicado: (2019)

Modelling the Effects of MCM7 Variants, Somatic Mutations, and Clinical Features on Acute Myeloid Leukemia Susceptibility and Prognosis
por: Tripon, Florin, et al.
Publicado: (2020)

From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia
por: Bănescu, Claudia, et al.
Publicado: (2016)

Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice
por: Wartman, Lukas D., et al.
Publicado: (2012)

Relapsed/refractory acute promyelocytic leukemia with RARA-LBD region mutation was salvaged by venetoclax: A case report
por: Li, Youli, et al.
Publicado: (2021)

Association of TLR4 Rs4986791 Polymorphism and TLR9 Haplotypes with Acute Myeloid Leukemia Susceptibility: A Case-Control Study of Adult Patients
por: Banescu, Claudia, et al.
Publicado: (2022)

Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study
por: Tripon, Florin, et al.
Publicado: (2020)

FLT3/ITD associated with an immature immunophenotype in PML-RARα leukemia
por: Takenokuchi, Mariko, et al.
Publicado: (2012)

Does acute promyelocytic leukemia patient with the STAT5B/RARa fusion gene respond well to decitabine?: A case report and literature review
por: Wang, Lei, et al.
Publicado: (2020)

Exon 21 deletion in the OPHN1 gene in a family with syndromic X-linked intellectual disability: Case report
por: Bogliş, Alina, et al.
Publicado: (2020)

Pathogenic Biallelic Mutations in ECHS1 in a Case with Short-Chain Enoyl-CoA Hydratase (SCEH) Deficiency-Case Report and Literature Review
por: Muntean, Carmen, et al.
Publicado: (2022)

Pitt-Hopkins Syndrome: Clinical and Molecular Findings of a 5-Year-Old Patient
por: Tripon, Florin, et al.
Publicado: (2020)

Educational Case: Acute Promyelocytic Leukemia With PML-RARA
por: Kunak, Rebecca L., et al.
Publicado: (2019)

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
por: Jaffray, Ellis G., et al.
Publicado: (2023)

A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
por: Yassin, Mohamed A., et al.
Publicado: (2020)

Analysis of pre-chemotherapy WBC, PLT, monocyte, hemoglobin, and MPV levels in acute myeloid leukemia patients with WT1, FLT3, or NPM gene mutations
por: Merdin, Alparslan, et al.
Publicado: (2020)

The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation
por: Liu, Xi, et al.
Publicado: (2014)

PML-RARA mutations confer varying arsenic trioxide resistance
por: Bai, Dong-Mei, et al.
Publicado: (2016)

Cytokine TGF-β1, TNF-α, IFN-γ and IL‐6 Gene Polymorphisms and Localization of Premalignant Gastric Lesions in Immunohistochemically H. pylori-negative Patients
por: Negovan, Anca, et al.
Publicado: (2021)

Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromosomal translocations in acute promyelocytic leukemia
por: Kim, Min Jin, et al.
Publicado: (2012)

A novel de novo MYH9 mutation in MYH9-related disease: A case report and review of literature
por: Ai, Qi, et al.
Publicado: (2020)

getITD for FLT3-ITD-based MRD monitoring in AML
por: Blätte, Tamara J., et al.
Publicado: (2019)

HNRNPC-RARA Fusion Gene in a Case with Acute Promyelocytic Leukemia Lacking PML-RARA Rearrangement Presenting with Abundant Hemophagocytosis
por: Tan, Jing, et al.
Publicado: (2023)

Adefovir dipivoxil inhibits APL progression through degradation of the oncoprotein PML-RARA
por: Gong, Xubo, et al.
Publicado: (2022)

FLT3-ITD signals bad news for core binding factor acute myeloid leukemia unless trisomy 22 comes to the rescue
por: Loo, Sun, et al.
Publicado: (2021)

CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study
por: Bănescu, Claudia, et al.
Publicado: (2014)

Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML
por: Wang, Aoli, et al.
Publicado: (2016)

Characterization of cryptic rearrangements, deletion, complex variants of PML, RARA in acute promyelocytic leukemia
por: Amare, Pratibha Kadam, et al.
Publicado: (2011)

The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients
por: Dunn, William G., et al.
Publicado: (2021)

Significant Associations between AXIN1 rs1805105, rs12921862, rs370681 Haplotypes and Variant Genotypes of AXIN2 rs2240308 with Risk of Congenital Heart Defects
por: Crauciuc, George Andrei, et al.
Publicado: (2020)

Arsenic trioxide induces autophagic degradation of the FLT3-ITD mutated protein in FLT3-ITD acute myeloid leukemia cells
por: Liu, Xiao-Jian, et al.
Publicado: (2020)

Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia
por: Albano, Francesco, et al.
Publicado: (2015)

Absence of natural intracellular retinoids in mouse bone marrow cells and implications for PML-RARA transformation
por: Niu, H, et al.
Publicado: (2015)

PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity
por: Noguera, Nélida Inés, et al.
Publicado: (2016)

Cytogenetically cryptic PML::RARA fusion in acute promyelocytic leukemia: Testing strategies in the modern era
por: Karlin, Kirill, et al.
Publicado: (2022)

Favorable outcome of PML‐RARα short isoform and FLT3‐ITD mutation in a patient with several adverse prognostic markers: A case report
por: Bafail, Mohammed A., et al.
Publicado: (2023)

Pattern and prognostic value of FLT3‐ITD mutations in Chinese de novo adult acute myeloid leukemia
por: Liu, Song‐Bai, et al.
Publicado: (2018)

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia
por: dos Santos, Guilherme Augusto, et al.
Publicado: (2013)

RUNX1 cooperates with FLT3-ITD to induce leukemia
por: Behrens, Kira, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n4usa5krt8np70brdm102mn597