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No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis

BACKGROUND: Various epidemiological studies have demonstrated the association between abortion and risk of breast cancer among nulliparous women; however, results remain inconclusive. This meta-analysis assessed the association based on previous studies. METHODS: PubMed, EMBase, China National Knowl...

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Autores principales: Tong, Huazhang, Wu, Yifan, Yan, Yin, Dong, Yonghai, Guan, Xihong, Liu, Yun, Lu, ZhiHui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220471/
https://www.ncbi.nlm.nih.gov/pubmed/32384520
http://dx.doi.org/10.1097/MD.0000000000020251
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author Tong, Huazhang
Wu, Yifan
Yan, Yin
Dong, Yonghai
Guan, Xihong
Liu, Yun
Lu, ZhiHui
author_facet Tong, Huazhang
Wu, Yifan
Yan, Yin
Dong, Yonghai
Guan, Xihong
Liu, Yun
Lu, ZhiHui
author_sort Tong, Huazhang
collection PubMed
description BACKGROUND: Various epidemiological studies have demonstrated the association between abortion and risk of breast cancer among nulliparous women; however, results remain inconclusive. This meta-analysis assessed the association based on previous studies. METHODS: PubMed, EMBase, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang databases were searched for relevant articles until February 2018. In this meta-analysis, fixed-effects models were used to estimate the combined effect size and the corresponding 95% confidence interval (CI). All statistical data were analyzed using STATA 12.0. RESULTS: A total of 14 articles consisting of 6 cohort studies and 8 case-control studies were included in this review. All articles were of high quality, as determined based on the Newcastle Ottawa Scale assessment. The combined risk ratio (RR) indicated no significant association between abortion and breast cancer among nulliparous women (RR = 1.023, 95%CI = 0.938–1.117; Z = 0.51, P = .607). Subgroup analyses revealed no significant associations between risk of breast cancer and induced abortion or between risk of breast cancer and spontaneous abortion (SA) among nulliparous women (RR = 1.008, 95% CI = 0.909-1.118 and RR = 1.062, 95%CI = 0.902-1.250, respectively). Neither 1 nor >2 abortions increased the risk of breast cancer among nulliparous women. Sensitivity analysis showed that our results were reliable and stable. CONCLUSION: Current evidence based on epidemiological studies showed no association between abortion and risk of breast cancer among nulliparous women.
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spelling pubmed-72204712020-06-15 No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis Tong, Huazhang Wu, Yifan Yan, Yin Dong, Yonghai Guan, Xihong Liu, Yun Lu, ZhiHui Medicine (Baltimore) 5700 BACKGROUND: Various epidemiological studies have demonstrated the association between abortion and risk of breast cancer among nulliparous women; however, results remain inconclusive. This meta-analysis assessed the association based on previous studies. METHODS: PubMed, EMBase, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang databases were searched for relevant articles until February 2018. In this meta-analysis, fixed-effects models were used to estimate the combined effect size and the corresponding 95% confidence interval (CI). All statistical data were analyzed using STATA 12.0. RESULTS: A total of 14 articles consisting of 6 cohort studies and 8 case-control studies were included in this review. All articles were of high quality, as determined based on the Newcastle Ottawa Scale assessment. The combined risk ratio (RR) indicated no significant association between abortion and breast cancer among nulliparous women (RR = 1.023, 95%CI = 0.938–1.117; Z = 0.51, P = .607). Subgroup analyses revealed no significant associations between risk of breast cancer and induced abortion or between risk of breast cancer and spontaneous abortion (SA) among nulliparous women (RR = 1.008, 95% CI = 0.909-1.118 and RR = 1.062, 95%CI = 0.902-1.250, respectively). Neither 1 nor >2 abortions increased the risk of breast cancer among nulliparous women. Sensitivity analysis showed that our results were reliable and stable. CONCLUSION: Current evidence based on epidemiological studies showed no association between abortion and risk of breast cancer among nulliparous women. Wolters Kluwer Health 2020-05-08 /pmc/articles/PMC7220471/ /pubmed/32384520 http://dx.doi.org/10.1097/MD.0000000000020251 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Tong, Huazhang
Wu, Yifan
Yan, Yin
Dong, Yonghai
Guan, Xihong
Liu, Yun
Lu, ZhiHui
No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis
title No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis
title_full No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis
title_fullStr No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis
title_full_unstemmed No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis
title_short No association between abortion and risk of breast cancer among nulliparous women: Evidence from a meta-analysis
title_sort no association between abortion and risk of breast cancer among nulliparous women: evidence from a meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220471/
https://www.ncbi.nlm.nih.gov/pubmed/32384520
http://dx.doi.org/10.1097/MD.0000000000020251
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