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Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer

PURPOSE: This study evaluated the analgesic effect of stereotactic body radiotherapy (SBRT) in combination with celiac plexus block (CPB), relative to SBRT alone, in locally advanced pancreatic cancer (LAPC) patients. PATIENTS AND METHODS: We reviewed medical records of all patients with LAPC, who r...

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Autores principales: Ji, Kai, Shao, Yue-Juan, Hao, Jian-Lei, Cheng, Xian-Jiang, Guan, Bing-Qing, Liu, Wei-Shuai, Chen, Lei, Wang, Xin, Song, Yong-Chun, Wang, Kun, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220540/
https://www.ncbi.nlm.nih.gov/pubmed/32440197
http://dx.doi.org/10.2147/JPR.S247303
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author Ji, Kai
Shao, Yue-Juan
Hao, Jian-Lei
Cheng, Xian-Jiang
Guan, Bing-Qing
Liu, Wei-Shuai
Chen, Lei
Wang, Xin
Song, Yong-Chun
Wang, Kun
Wang, Ping
author_facet Ji, Kai
Shao, Yue-Juan
Hao, Jian-Lei
Cheng, Xian-Jiang
Guan, Bing-Qing
Liu, Wei-Shuai
Chen, Lei
Wang, Xin
Song, Yong-Chun
Wang, Kun
Wang, Ping
author_sort Ji, Kai
collection PubMed
description PURPOSE: This study evaluated the analgesic effect of stereotactic body radiotherapy (SBRT) in combination with celiac plexus block (CPB), relative to SBRT alone, in locally advanced pancreatic cancer (LAPC) patients. PATIENTS AND METHODS: We reviewed medical records of all patients with LAPC, who received SBRT between 1 January 2017 to 31 August 2019 at our center. The average numeric rating scale (NRS) of ≥3 was used in all patients at admission. We recorded average and worst NRS in a 24-hour period, and daily narcotic doses before SBRT, followed by weekly for 1 month and monthly for 3 months. RESULTS: A total of 23 patients in the SBRT group and 12 under SBRT+CPB who met the inclusion criteria were enrolled. All patients in the SBRT+CPB group received CPB within 10 days after SBRT. Pain intensity and narcotic consumption were comparable in both groups at initial assessment. However, a significant decrease (P < 0.05) in average NRS was recorded in the SBRT+CPB group relative to SBRT at 2, 3 and 4 weeks after SBRT. A comparison of daily narcotic consumption with baseline values showed a significant decrease in the SBRT+CPB group at 3 and 4 weeks after SBRT (P < 0.05), while no significant differences were observed in the SBRT group. CONCLUSION: CPB after SBRT appears to be an effective therapeutic option in patients with LAPC and warrants further evaluation with increased number of patients in prospective clinical trials.
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spelling pubmed-72205402020-05-21 Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer Ji, Kai Shao, Yue-Juan Hao, Jian-Lei Cheng, Xian-Jiang Guan, Bing-Qing Liu, Wei-Shuai Chen, Lei Wang, Xin Song, Yong-Chun Wang, Kun Wang, Ping J Pain Res Original Research PURPOSE: This study evaluated the analgesic effect of stereotactic body radiotherapy (SBRT) in combination with celiac plexus block (CPB), relative to SBRT alone, in locally advanced pancreatic cancer (LAPC) patients. PATIENTS AND METHODS: We reviewed medical records of all patients with LAPC, who received SBRT between 1 January 2017 to 31 August 2019 at our center. The average numeric rating scale (NRS) of ≥3 was used in all patients at admission. We recorded average and worst NRS in a 24-hour period, and daily narcotic doses before SBRT, followed by weekly for 1 month and monthly for 3 months. RESULTS: A total of 23 patients in the SBRT group and 12 under SBRT+CPB who met the inclusion criteria were enrolled. All patients in the SBRT+CPB group received CPB within 10 days after SBRT. Pain intensity and narcotic consumption were comparable in both groups at initial assessment. However, a significant decrease (P < 0.05) in average NRS was recorded in the SBRT+CPB group relative to SBRT at 2, 3 and 4 weeks after SBRT. A comparison of daily narcotic consumption with baseline values showed a significant decrease in the SBRT+CPB group at 3 and 4 weeks after SBRT (P < 0.05), while no significant differences were observed in the SBRT group. CONCLUSION: CPB after SBRT appears to be an effective therapeutic option in patients with LAPC and warrants further evaluation with increased number of patients in prospective clinical trials. Dove 2020-05-04 /pmc/articles/PMC7220540/ /pubmed/32440197 http://dx.doi.org/10.2147/JPR.S247303 Text en © 2020 Ji et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ji, Kai
Shao, Yue-Juan
Hao, Jian-Lei
Cheng, Xian-Jiang
Guan, Bing-Qing
Liu, Wei-Shuai
Chen, Lei
Wang, Xin
Song, Yong-Chun
Wang, Kun
Wang, Ping
Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer
title Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer
title_full Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer
title_fullStr Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer
title_full_unstemmed Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer
title_short Celiac Plexus Block After Stereotactic Body Radiotherapy Improves Pain Relief in Locally Advanced Pancreatic Cancer
title_sort celiac plexus block after stereotactic body radiotherapy improves pain relief in locally advanced pancreatic cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220540/
https://www.ncbi.nlm.nih.gov/pubmed/32440197
http://dx.doi.org/10.2147/JPR.S247303
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