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Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis

BACKGROUND: microRNAs have drawn more attention due to their function on the inflammatory process. The association between microRNA-21 (miR-21) expression and risk of inflammatory bowel diseases (IBD) remain inconclusive. This study was aimed to acquire a more exact estimation of this relationship....

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Detalles Bibliográficos
Autores principales: Yan, Huimin, Zhang, Xinyu, Xu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220677/
https://www.ncbi.nlm.nih.gov/pubmed/32332611
http://dx.doi.org/10.1097/MD.0000000000019693
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author Yan, Huimin
Zhang, Xinyu
Xu, Yi
author_facet Yan, Huimin
Zhang, Xinyu
Xu, Yi
author_sort Yan, Huimin
collection PubMed
description BACKGROUND: microRNAs have drawn more attention due to their function on the inflammatory process. The association between microRNA-21 (miR-21) expression and risk of inflammatory bowel diseases (IBD) remain inconclusive. This study was aimed to acquire a more exact estimation of this relationship. METHODS: Relevant studies were identified through searching PubMed, Embase, Wanfang, and China National Knowledge Infrastructure database. Pooled standardized mean difference and 95% confidence intervals were calculated using a random-effect model. Publication bias test, sensitivity analysis and subgroup analysis were carried out. RESULTS: A total of 20 relevant articles comprising 540 patients with ulcerative colitis (UC), 459 patients with Crohn disease (CD) and 511 non-IBD controls were included in this analysis. The expression of miR-21 was significantly increased in colon tissue of both UC and CD patients compared with non-IBD controls. However, there were no significant differences between patients with UC and CD. Moreover, increased miR-21 expression was associated with disease activity status in UC patients, but not in CD patients. CONCLUSIONS: This meta-analysis demonstrates that the higher miR-21 expression in colon tissue is positively associated with the development of UC and CD, and miR-21 might serve as a disease marker of IBD.
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spelling pubmed-72206772020-06-15 Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis Yan, Huimin Zhang, Xinyu Xu, Yi Medicine (Baltimore) 4500 BACKGROUND: microRNAs have drawn more attention due to their function on the inflammatory process. The association between microRNA-21 (miR-21) expression and risk of inflammatory bowel diseases (IBD) remain inconclusive. This study was aimed to acquire a more exact estimation of this relationship. METHODS: Relevant studies were identified through searching PubMed, Embase, Wanfang, and China National Knowledge Infrastructure database. Pooled standardized mean difference and 95% confidence intervals were calculated using a random-effect model. Publication bias test, sensitivity analysis and subgroup analysis were carried out. RESULTS: A total of 20 relevant articles comprising 540 patients with ulcerative colitis (UC), 459 patients with Crohn disease (CD) and 511 non-IBD controls were included in this analysis. The expression of miR-21 was significantly increased in colon tissue of both UC and CD patients compared with non-IBD controls. However, there were no significant differences between patients with UC and CD. Moreover, increased miR-21 expression was associated with disease activity status in UC patients, but not in CD patients. CONCLUSIONS: This meta-analysis demonstrates that the higher miR-21 expression in colon tissue is positively associated with the development of UC and CD, and miR-21 might serve as a disease marker of IBD. Wolters Kluwer Health 2020-04-24 /pmc/articles/PMC7220677/ /pubmed/32332611 http://dx.doi.org/10.1097/MD.0000000000019693 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4500
Yan, Huimin
Zhang, Xinyu
Xu, Yi
Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis
title Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis
title_full Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis
title_fullStr Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis
title_full_unstemmed Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis
title_short Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta analysis
title_sort aberrant expression of mir-21 in patients with inflammatory bowel disease: a protocol for systematic review and meta analysis
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220677/
https://www.ncbi.nlm.nih.gov/pubmed/32332611
http://dx.doi.org/10.1097/MD.0000000000019693
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