Deletion of the Tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB/N mouse strain

Tensin2 (TNS2) is a focal adhesion-localized protein possessing N-terminal tandem protein tyrosine phosphatase (PTPase) and C2 domains, and C-terminal tandem Src homology 2 (SH2) and phosphotyrosine binding (PTB) domains. Genetic deletion of Tns2 in a susceptible murine strain leads to podocyte alte...

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Detalles Bibliográficos
Autores principales: Sasaki, Hayato, Takahashi, Yuki, Ogawa, Tsubasa, Hiura, Koki, Nakano, Kenta, Sugiyama, Makoto, Okamura, Tadashi, Sasaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2019
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220710/
https://www.ncbi.nlm.nih.gov/pubmed/31723089
http://dx.doi.org/10.1538/expanim.19-0101

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