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Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer

RATIONALE AND OBJECTIVES: To evaluate the diagnostic performance of abbreviated screening breast magnetic resonance imaging (AB-MRI) for screening in women with previously treated breast cancer. MATERIALS AND METHODS: This retrospective study included consecutive AB-MRI from September 2015 to Decemb...

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Autores principales: Kwon, Mi-ri, Ko, Eun Young, Han, Boo-Kyung, Ko, Eun Sook, Choi, Ji Soo, Park, Ko Woon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220756/
https://www.ncbi.nlm.nih.gov/pubmed/32311941
http://dx.doi.org/10.1097/MD.0000000000019676
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author Kwon, Mi-ri
Ko, Eun Young
Han, Boo-Kyung
Ko, Eun Sook
Choi, Ji Soo
Park, Ko Woon
author_facet Kwon, Mi-ri
Ko, Eun Young
Han, Boo-Kyung
Ko, Eun Sook
Choi, Ji Soo
Park, Ko Woon
author_sort Kwon, Mi-ri
collection PubMed
description RATIONALE AND OBJECTIVES: To evaluate the diagnostic performance of abbreviated screening breast magnetic resonance imaging (AB-MRI) for screening in women with previously treated breast cancer. MATERIALS AND METHODS: This retrospective study included consecutive AB-MRI from September 2015 to December 2016 in patients with previously treated breast cancer. Longitudinal medical record of patients’ demographics, outcomes of imaging surveillance and results of biopsy was reviewed. Protocol consisted of T2-weighted scanning and dynamic contrast-enhanced imaging including one pre-contrast and two post-contrast scans. A positive examination was defined as final assessment of BI-RADS 4 or 5 and negative was defined as BI-RADS 1, 2, or 3. Abnormal interpretation rate, cancer detection rate (CDR), sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) were analyzed. RESULTS: Among total 1043 AB-MRI, 29 (2.8%) AB-MRI had suspicious findings including 26 (2.5%) BI-RADS 4 and 3 (0.3%) BI-RADS 5 assessments. CDR was 9.59 per 1000. Performance outcomes were as follows: sensitivity, 71.4%; specificity, 98.2%; accuracy, 97.8%; PPV 1, 35.7%; PPV3 50%; and NPV 99.6%. Four cancers with false negative MRI were all early cancers of <1.0 cm with node negative. One was palpable interval cancer while the others were alternative screening modality-detected asymptomatic cancers before the next MRI screening. CONCLUSION: AB-MRI showed high accuracy and NPV for detecting cancer recurrence in women with previously treated breast cancer. Missed cancers were all minimal cancers with node negative.
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spelling pubmed-72207562020-06-15 Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer Kwon, Mi-ri Ko, Eun Young Han, Boo-Kyung Ko, Eun Sook Choi, Ji Soo Park, Ko Woon Medicine (Baltimore) 6800 RATIONALE AND OBJECTIVES: To evaluate the diagnostic performance of abbreviated screening breast magnetic resonance imaging (AB-MRI) for screening in women with previously treated breast cancer. MATERIALS AND METHODS: This retrospective study included consecutive AB-MRI from September 2015 to December 2016 in patients with previously treated breast cancer. Longitudinal medical record of patients’ demographics, outcomes of imaging surveillance and results of biopsy was reviewed. Protocol consisted of T2-weighted scanning and dynamic contrast-enhanced imaging including one pre-contrast and two post-contrast scans. A positive examination was defined as final assessment of BI-RADS 4 or 5 and negative was defined as BI-RADS 1, 2, or 3. Abnormal interpretation rate, cancer detection rate (CDR), sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) were analyzed. RESULTS: Among total 1043 AB-MRI, 29 (2.8%) AB-MRI had suspicious findings including 26 (2.5%) BI-RADS 4 and 3 (0.3%) BI-RADS 5 assessments. CDR was 9.59 per 1000. Performance outcomes were as follows: sensitivity, 71.4%; specificity, 98.2%; accuracy, 97.8%; PPV 1, 35.7%; PPV3 50%; and NPV 99.6%. Four cancers with false negative MRI were all early cancers of <1.0 cm with node negative. One was palpable interval cancer while the others were alternative screening modality-detected asymptomatic cancers before the next MRI screening. CONCLUSION: AB-MRI showed high accuracy and NPV for detecting cancer recurrence in women with previously treated breast cancer. Missed cancers were all minimal cancers with node negative. Wolters Kluwer Health 2020-04-17 /pmc/articles/PMC7220756/ /pubmed/32311941 http://dx.doi.org/10.1097/MD.0000000000019676 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 6800
Kwon, Mi-ri
Ko, Eun Young
Han, Boo-Kyung
Ko, Eun Sook
Choi, Ji Soo
Park, Ko Woon
Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer
title Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer
title_full Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer
title_fullStr Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer
title_full_unstemmed Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer
title_short Diagnostic performance of abbreviated breast MRI for screening of women with previously treated breast cancer
title_sort diagnostic performance of abbreviated breast mri for screening of women with previously treated breast cancer
topic 6800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220756/
https://www.ncbi.nlm.nih.gov/pubmed/32311941
http://dx.doi.org/10.1097/MD.0000000000019676
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